Growing up with HIV: Children, adolescents, and young adults with perinatally acquired HIV infection

Rohan Hazra, George K. Siberry, Lynne M. Mofenson

Research output: Contribution to journalReview articlepeer-review

154 Scopus citations


Tremendous success in the prevention and treatment of pediatric HIV in high-resource countries has changed the face of the epidemic. A perinatally HIV-infected child now faces a chronic disease rather than a progressive, fatal one. However, these successes pose new challenges as perinatally HIV-infected youth survive into adulthood. These include maintaining adherence to long-term, likely life-long therapy; selecting successive antiretroviral drug regimens, given the limited availability of pediatric formulations and the lack of pharmacokinetic and safety data in children; and overcoming extensive drug resistance in multi-drug-experienced children. Pediatric HIV care now focuses on morbidity related to long-term HIV infection and its treatment. Survival into adulthood of perinatally HIV-infected youth in high-resource countries encourages expansion of pediatric treatment programs in low-resource countries, where most HIV-infected children live, and provides important lessons about how the epidemic changes with increasing access to antiretroviral therapy for children.

Original languageEnglish (US)
Pages (from-to)169-185
Number of pages17
JournalAnnual review of medicine
StatePublished - Feb 18 2010


  • Highly active antiretroviral therapy
  • Human immunodeficiency virus
  • Metabolic complications
  • Mother-to-child transmission
  • Pediatric HIV infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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