Abstract
Group sequential tests for the analysis of survival data that compare two treatments and allow for the adjustment of other concomitant variables are discussed. These methods allow early termination of a study if large treatment differences occur. Based on simulation results, we compare the operating characteristics of these adjusted tests with the unadjusted sequentially-computed log rank test.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 365-373 |
| Number of pages | 9 |
| Journal | Biometrika |
| Volume | 72 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 1985 |
| Externally published | Yes |
Keywords
- Asymptotic normality
- Counting process
- Covariate
- Group sequential test
- Survival analysis
ASJC Scopus subject areas
- Statistics and Probability
- General Mathematics
- Agricultural and Biological Sciences (miscellaneous)
- General Agricultural and Biological Sciences
- Statistics, Probability and Uncertainty
- Applied Mathematics
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