TY - JOUR
T1 - Group choreography
T2 - Mechanisms orchestrating the collective movement of border cells
AU - Montell, Denise J.
AU - Yoon, Wan Hee
AU - Starz-Gaiano, Michelle
N1 - Funding Information:
M. S. G. is funded by a Basil O’Connor Starter Scholar Award from the March of Dimes and a CAREER Award (1054422) from the National Science Foundation. D. J. M. is supported by R01GM46425 and R01GM73164 from the National Institutes of General Medical Sciences. The authors would like to thank current and previous members of the Montell laboratory for providing the images in Figure 1 (Image in figure 1b is courtesy of Ho Lam Tang, image in part b is courtesy of Yu Chiuan Chang, image in part d is courtesy of Mohit Prasad and image in part f is courtesy of Anna Jang).
PY - 2012/10
Y1 - 2012/10
N2 - Cell movements are essential for animal development and homeostasis but also contribute to disease. Moving cells typically extend protrusions towards a chemoattractant, adhere to the substrate, contract and detach at the rear. It is less clear how cells that migrate in interconnected groups in vivo coordinate their behaviour and navigate through natural environments. The border cells of the Drosophila melanogaster ovary have emerged as an excellent model for the study of collective cell movement, aided by innovative genetic, live imaging, and photomanipulation techniques. Here we provide an overview of the molecular choreography of border cells and its more general implications.
AB - Cell movements are essential for animal development and homeostasis but also contribute to disease. Moving cells typically extend protrusions towards a chemoattractant, adhere to the substrate, contract and detach at the rear. It is less clear how cells that migrate in interconnected groups in vivo coordinate their behaviour and navigate through natural environments. The border cells of the Drosophila melanogaster ovary have emerged as an excellent model for the study of collective cell movement, aided by innovative genetic, live imaging, and photomanipulation techniques. Here we provide an overview of the molecular choreography of border cells and its more general implications.
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U2 - 10.1038/nrm3433
DO - 10.1038/nrm3433
M3 - Review article
C2 - 23000794
AN - SCOPUS:84866665407
SN - 1471-0072
VL - 13
SP - 631
EP - 645
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 10
ER -