Graphene oxide-gadolinium (III) oxide nanoparticle composite: A novel MR contrast agent with high longitudinal and transverse relaxivity

N. Venkatesha, Pavan Poojar, Sairam Geethanath, Chandan Srivastava

Research output: Contribution to journalArticlepeer-review

Abstract

Production of bio-compatible contrast agent materials to enhance the sensitivity of the magnetic resonance imaging (MRI) technique is a highly active area in MRI related research. This work illustrates the potential of a new material: graphene oxide-gadolinium (III) oxide nanoparticle (GO-Gd2O3) composite in yielding both transverse (16.3mM-1 s-1) and longitudinal relaxivity (40mM-1 s-1) values which are significantly higher than the proton relaxivity values achieved using the gadolinium based contrast agents currently used in MRI. Such high proton relaxivity values can facilitate low dosage of GO-Gd2O3 composite for obtaining both T1 and T2 weighted high signal-to-noise ratio images in MRI.

Original languageEnglish (US)
Article number045008
JournalMaterials Research Express
Volume1
Issue number4
DOIs
StatePublished - Dec 2015
Externally publishedYes

Keywords

  • Graphene oxide
  • MRI contrast agents
  • Nanoparticles
  • Proton relaxivity

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Metals and Alloys

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