TY - GEN
T1 - Granger causality analysis reveals the changes of thalamocortical functionality after cardiac arrest induced hypoxic-ischemic injury
AU - Chen, Cheng
AU - Maybhate, Anil
AU - Thakor, Nitish V.
PY - 2012/6/29
Y1 - 2012/6/29
N2 - Hypoxic-ischemia (HI) following cardiac arrest (CA) induces a global injury to the brain that can lead to coma. Resuscitation may eventually lead to arousal from coma. During early arousal, how the functional connectivity between various important brain regions evolves may ultimately affect the outcome. In order to understand the changes in thalamocortical functionality through the injury and recovery periods, we recorded local field potentials (LFPs) from the ventroposterior lateral (VPL) nucleus of the thalamus and the forelimb somatosensory cortex (S1-FL) in a rat model of asphyxial CA. Granger causality was used to analyze the causal relationships between the thalamocortical LFPs. Preliminary results indicate that during early arousal, the thalamocortical dynamics is significantly unilateral with the thalamic centers driving the cortical regions and the driving strength decreased significantly upon CA and improved after resuscitation during arousal.
AB - Hypoxic-ischemia (HI) following cardiac arrest (CA) induces a global injury to the brain that can lead to coma. Resuscitation may eventually lead to arousal from coma. During early arousal, how the functional connectivity between various important brain regions evolves may ultimately affect the outcome. In order to understand the changes in thalamocortical functionality through the injury and recovery periods, we recorded local field potentials (LFPs) from the ventroposterior lateral (VPL) nucleus of the thalamus and the forelimb somatosensory cortex (S1-FL) in a rat model of asphyxial CA. Granger causality was used to analyze the causal relationships between the thalamocortical LFPs. Preliminary results indicate that during early arousal, the thalamocortical dynamics is significantly unilateral with the thalamic centers driving the cortical regions and the driving strength decreased significantly upon CA and improved after resuscitation during arousal.
UR - https://www.scopus.com/pages/publications/84862750527
UR - https://www.scopus.com/pages/publications/84862750527#tab=citedBy
U2 - 10.1109/NEBC.2012.6206963
DO - 10.1109/NEBC.2012.6206963
M3 - Conference contribution
AN - SCOPUS:84862750527
SN - 9781467311410
T3 - 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
SP - 63
EP - 64
BT - 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
T2 - 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Y2 - 16 March 2012 through 18 March 2012
ER -