Gradient-enhanced 3D NOESY-HMQC spectroscopy

Geerten W. Vuister, Rolf Boelens, Robert Kaptein, Maurits Burgering, Peter C.M. van Zijl

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


A gradient-enhanced 3D NOESY-HMQC experiment is presented and applied to15N-labeled Mnt repressor (1-76) in1H2O. Both coherence selection and1H2O suppression are achieved using gradients. A singlescan experiment can be recorded for each time increment, which greatly reduces recording time with respect to conventional methods using phase cycling. This can be of use for kinetic studies and for relatively unstable molecules.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalJournal of Biomolecular NMR
Issue number3
StatePublished - May 1992
Externally publishedYes


  • 3D NMR
  • Gradient-enhanced NMR
  • Mnt repressor

ASJC Scopus subject areas

  • Biochemistry
  • Spectroscopy


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