Graded isavuconazole introduction in a patient with voriconazole allergy

Megan K. Morales, Ché Harris, Shmuel Shoham

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Triazole antifungal drugs may rarely cause serious allergic reactions including angioedema. No standardized tests are available to predict cross-reactivity within the azole class and little guiding information exists on whether to change therapy within the class or to another class after a serious allergic reaction. Herein we report the first successful use, to our knowledge, of graded isavuconazole introduction for treatment of aspergillosis in a liver transplant recipient with severe voriconazole allergy.

Original languageEnglish (US)
Article numbere12772
JournalTransplant Infectious Disease
Issue number6
StatePublished - Dec 2017


  • angioedema
  • azole allergy
  • azole cross-reactivity
  • isavuconazole challenge
  • voriconazole allergy

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation


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