Gonadotropin stimulation for in vitro fertilization and embryo transfer in insulin-dependent diabetics: Follicular response, oocyte quality, embryo development, and follicular environment

Two IDD patients were stimulated with gonadotropins for IVF and ET. Both patients had high E₂ response and ≥5 preovulatory oocytes retrieved, normal fertilization and cleavage rates, and transfer; neither conceived. Follicular fluid showed levels of E₂, P, A, hCG, and PRL similar to non-IDD. Epidermal growth factor could not be detected in FF. Insulin-dependent diabetes patients can undergo gonadotropin stimulation for IVF with customary responses. Their follicular milieu resembles that of non-IDD patients except for a lack of EGF.