Gonadotropin-releasing hormone plasticity: A comparative perspective

T. J. Stevenson, T. P. Hahn, S. A. MacDougall-Shackleton, G. F. Ball

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Gonadotropin-releasing hormone 1 (GnRH1) is a key regulator of the reproductive neuroendocrine system in vertebrates. Recent developments have suggested that GnRH1 neurons exhibit far greater plasticity at the cellular and molecular levels than previously thought. Furthermore, there is growing evidence that sub-populations of GnRH1 neurons in the preoptic area are highly responsive to specific environmental and hormonal conditions. In this paper we discuss findings that reveal large variation in GnRH1 mRNA and protein expression that are regulated by social cues, photoperiod, and hormonal feedback. We draw upon studies using histochemistry and immediate early genes (e.g., c-FOS/ZENK) to illustrate that specific groups of GnRH1 neurons are topographically organized. Based on data from diverse vertebrate species, we suggest that GnRH1 expression within individuals is temporally dynamic and this plasticity may be evolutionarily conserved. We suggest that the plasticity observed in other neuropeptide systems (i.e. kisspeptin) may have evolved in a similar manner.

Original languageEnglish (US)
Pages (from-to)287-300
Number of pages14
JournalFrontiers in Neuroendocrinology
Issue number3
StatePublished - Aug 2012
Externally publishedYes


  • Feedback
  • GnRH1
  • Gonadotropins
  • Kisspeptin
  • LH surge
  • LHRH
  • Reproduction
  • Vertebrate

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems


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