TY - JOUR
T1 - GlyTouCan 1.0 - The international glycan structure repository
AU - Aoki-Kinoshita, Kiyoko
AU - Agravat, Sanjay
AU - Aoki, Nobuyuki P.
AU - Arpinar, Sena
AU - Cummings, Richard D.
AU - Fujita, Akihiro
AU - Fujita, Noriaki
AU - Hart, Gerald Warren
AU - Haslam, Stuart M.
AU - Kawasaki, Toshisuke
AU - Matsubara, Masaaki
AU - Moreman, Kelley W.
AU - Okuda, Shujiro
AU - Pierce, Michael
AU - Ranzinger, René
AU - Shikanai, Toshihide
AU - Shinmachi, Daisuke
AU - Solovieva, Elena
AU - Suzuki, Yoshinori
AU - Tsuchiya, Shinichiro
AU - Yamada, Issaku
AU - York, William S.
AU - Zaia, Joseph
AU - Narimatsu, Hisashi
PY - 2016
Y1 - 2016
N2 - Glycans are known as the third major class of biopolymers, next to DNA and proteins. They cover the surfaces of many cells, serving as the 'face' of cells, whereby other biomolecules and viruses interact. The structure of glycans, however, differs greatly from DNA and proteins in that they are branched, as opposed to linear sequences of amino acids or nucleotides. Therefore, the storage of glycan information in databases, let alone their curation, has been a difficult problem. This has caused many duplicated efforts when integration is attempted between different databases, making an international repository for glycan structures, where unique accession numbers are assigned to every identified glycan structure, necessary. As such, an international team of developers and glycobiologists have collaborated to develop this repository, called GlyTouCan and is available at http://glytoucan.org/, to provide a centralized resource for depositing glycan structures, compositions and topologies, and to retrieve accession numbers for each of these registered entries. This will thus enable researchers to reference glycan structures simply by accession number, as opposed to by chemical structure, which has been a burden to integrate glycomics databases in the past.
AB - Glycans are known as the third major class of biopolymers, next to DNA and proteins. They cover the surfaces of many cells, serving as the 'face' of cells, whereby other biomolecules and viruses interact. The structure of glycans, however, differs greatly from DNA and proteins in that they are branched, as opposed to linear sequences of amino acids or nucleotides. Therefore, the storage of glycan information in databases, let alone their curation, has been a difficult problem. This has caused many duplicated efforts when integration is attempted between different databases, making an international repository for glycan structures, where unique accession numbers are assigned to every identified glycan structure, necessary. As such, an international team of developers and glycobiologists have collaborated to develop this repository, called GlyTouCan and is available at http://glytoucan.org/, to provide a centralized resource for depositing glycan structures, compositions and topologies, and to retrieve accession numbers for each of these registered entries. This will thus enable researchers to reference glycan structures simply by accession number, as opposed to by chemical structure, which has been a burden to integrate glycomics databases in the past.
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U2 - 10.1093/nar/gkv1041
DO - 10.1093/nar/gkv1041
M3 - Article
C2 - 26476458
AN - SCOPUS:84979497739
SN - 0305-1048
VL - 44
SP - D1237-D1242
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
ER -