Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia

Jessica Jackson, William Eaton, Nicola Cascella, Alessio Fasano, Debby Santora, Kelli Sullivan, Stephanie Feldman, Heather Raley, Robert P. McMahon, William T. Carpenter, Haley Demyanovich, Deanna L. Kelly

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The relationship between gluten sensitivity and schizophrenia has been of increasing interest and novel mechanisms explaining this relationship continue to be described. Our study in 100 people with schizophrenia compared to 100 matched controls replicates a higher prevalence of gluten sensitivity and higher mean antigliadin IgG antibody levels schizophrenia (2.9 ± 7.7 vs 1.3 ± 1.3, p = 0.046, controlled for age). Additionally, we examined symptoms within the schizophrenia group and found that while positive symptoms are significantly lower in people who have elevated antigliadin antibodies (AGA; 4.11 ± 1.36 vs 6.39 ± 2.99, p = 0.020), no robust clinical profile differentiates between positive and negative antibody groups. Thus, identifying people in schizophrenia who may benefit from a gluten-free diet remains possible by blood test only.

Original languageEnglish (US)
Pages (from-to)539-542
Number of pages4
JournalSchizophrenia Research
Issue number2-3
StatePublished - Nov 1 2014


  • Celiac disease
  • Gliadin
  • Gluten
  • Gluten sensitivity
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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