Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia

Jessica Jackson; William Eaton; Nicola Cascella; Alessio Fasano; Debby Santora; Kelli Sullivan; Stephanie Feldman; Heather Raley; Robert P. McMahon; William T. Carpenter; Haley Demyanovich; Deanna L. Kelly

doi:10.1016/j.schres.2014.09.023

Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia

Jessica Jackson, William Eaton, Nicola Cascella, Alessio Fasano, Debby Santora, Kelli Sullivan, Stephanie Feldman, Heather Raley, Robert P. McMahon, William T. Carpenter, Haley Demyanovich, Deanna L. Kelly

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The relationship between gluten sensitivity and schizophrenia has been of increasing interest and novel mechanisms explaining this relationship continue to be described. Our study in 100 people with schizophrenia compared to 100 matched controls replicates a higher prevalence of gluten sensitivity and higher mean antigliadin IgG antibody levels schizophrenia (2.9 ± 7.7 vs 1.3 ± 1.3, p = 0.046, controlled for age). Additionally, we examined symptoms within the schizophrenia group and found that while positive symptoms are significantly lower in people who have elevated antigliadin antibodies (AGA; 4.11 ± 1.36 vs 6.39 ± 2.99, p = 0.020), no robust clinical profile differentiates between positive and negative antibody groups. Thus, identifying people in schizophrenia who may benefit from a gluten-free diet remains possible by blood test only.

Original language	English (US)
Pages (from-to)	539-542
Number of pages	4
Journal	Schizophrenia Research
Volume	159
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2014.09.023
State	Published - Nov 1 2014

Keywords

Celiac disease
Gliadin
Gluten
Gluten sensitivity
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2014.09.023

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title = "Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia",

abstract = "The relationship between gluten sensitivity and schizophrenia has been of increasing interest and novel mechanisms explaining this relationship continue to be described. Our study in 100 people with schizophrenia compared to 100 matched controls replicates a higher prevalence of gluten sensitivity and higher mean antigliadin IgG antibody levels schizophrenia (2.9 ± 7.7 vs 1.3 ± 1.3, p = 0.046, controlled for age). Additionally, we examined symptoms within the schizophrenia group and found that while positive symptoms are significantly lower in people who have elevated antigliadin antibodies (AGA; 4.11 ± 1.36 vs 6.39 ± 2.99, p = 0.020), no robust clinical profile differentiates between positive and negative antibody groups. Thus, identifying people in schizophrenia who may benefit from a gluten-free diet remains possible by blood test only.",

keywords = "Celiac disease, Gliadin, Gluten, Gluten sensitivity, Schizophrenia",

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AU - Jackson, Jessica

AU - Eaton, William

AU - Cascella, Nicola

AU - Fasano, Alessio

AU - Santora, Debby

AU - Sullivan, Kelli

AU - Feldman, Stephanie

AU - Raley, Heather

AU - McMahon, Robert P.

AU - Carpenter, William T.

AU - Demyanovich, Haley

AU - Kelly, Deanna L.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - The relationship between gluten sensitivity and schizophrenia has been of increasing interest and novel mechanisms explaining this relationship continue to be described. Our study in 100 people with schizophrenia compared to 100 matched controls replicates a higher prevalence of gluten sensitivity and higher mean antigliadin IgG antibody levels schizophrenia (2.9 ± 7.7 vs 1.3 ± 1.3, p = 0.046, controlled for age). Additionally, we examined symptoms within the schizophrenia group and found that while positive symptoms are significantly lower in people who have elevated antigliadin antibodies (AGA; 4.11 ± 1.36 vs 6.39 ± 2.99, p = 0.020), no robust clinical profile differentiates between positive and negative antibody groups. Thus, identifying people in schizophrenia who may benefit from a gluten-free diet remains possible by blood test only.

AB - The relationship between gluten sensitivity and schizophrenia has been of increasing interest and novel mechanisms explaining this relationship continue to be described. Our study in 100 people with schizophrenia compared to 100 matched controls replicates a higher prevalence of gluten sensitivity and higher mean antigliadin IgG antibody levels schizophrenia (2.9 ± 7.7 vs 1.3 ± 1.3, p = 0.046, controlled for age). Additionally, we examined symptoms within the schizophrenia group and found that while positive symptoms are significantly lower in people who have elevated antigliadin antibodies (AGA; 4.11 ± 1.36 vs 6.39 ± 2.99, p = 0.020), no robust clinical profile differentiates between positive and negative antibody groups. Thus, identifying people in schizophrenia who may benefit from a gluten-free diet remains possible by blood test only.

KW - Celiac disease

KW - Gliadin

KW - Gluten

KW - Gluten sensitivity

KW - Schizophrenia

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Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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