Glutathione levels and immune responses in tuberculosis patients

Vishwanath Venketaraman, Ariel Millman, Marwa Salman, Shobha Swaminathan, Mary Goetz, Alfred Lardizabal, Hom David Hom, Nancy D. Connell

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Glutathione levels are significantly reduced in peripheral blood mononuclear cells and red blood cells isolated from tuberculosis patients. Treatment of blood cultures from tuberculosis patients with N-acetyl cysteine, a glutathione precursor, was associated with improved control of intracellular M. tuberculosis infection. N-acetyl-cysteine treatment decreased the levels of IL-10, IL-6, TNF-α and IL-1, in blood cultures derived from tuberculosis patients, favoring the host immune cells to successfully control M. tuberculosis replication.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalMicrobial Pathogenesis
Volume44
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Keywords

  • Glutathione
  • Tuberculosis immunity

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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