Glutamine synthetase inhibition prevents cerebral oedema during hyperammonemia.

H. Takahashi, R. C. Koehler, S. W. Brusilow, R. J. Traystman

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The relationship between cerebral oedema and cerebral glutamine accumulation was investigated during acute hyperammonemia in anesthetized rats. Six hours of ammonium acetate infusion resulted in an increase in cortical glutamine concentration and a decrease in specific gravity. Pretreatment with methionine sulfoximine inhibited glutamine synthetase, prevented the increase in glutamine during hyperammonemia, and prevented the decrease in specific gravity. We conclude that the increase in brain water content is linked to the glutamine accumulation derived from the detoxification of ammonia by glutamine synthetase.

Original languageEnglish (US)
Pages (from-to)346-347
Number of pages2
JournalActa neurochirurgica. Supplementum
StatePublished - 1990

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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