Glutamine Skipping the Q into Mitochondria

Zachary E. Stine; Chi V. Dang

doi:10.1016/j.molmed.2019.11.004

Glutamine Skipping the Q into Mitochondria

Zachary E. Stine, Chi V. Dang

Research output: Contribution to journal › Short survey › peer-review

Abstract

Imported across the plasma membrane by SLC1A5, glutamine has emerged as a metabolic fuel that is catabolized by mitochondrial glutaminase to support tumor growth. The missing link between cytoplasmic and mitochondrial glutamine metabolism is now provided by Yoo et al., identifying the mitochondrial glutamine importer as a variant of SLC1A5.

Original language	English (US)
Pages (from-to)	6-7
Number of pages	2
Journal	Trends in Molecular Medicine
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.molmed.2019.11.004
State	Published - Jan 2020
Externally published	Yes

Keywords

alternative promoter
glutamine
hypoxia
metabolism
mitochondria
transporter

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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10.1016/j.molmed.2019.11.004

Cite this

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title = "Glutamine Skipping the Q into Mitochondria",

abstract = "Imported across the plasma membrane by SLC1A5, glutamine has emerged as a metabolic fuel that is catabolized by mitochondrial glutaminase to support tumor growth. The missing link between cytoplasmic and mitochondrial glutamine metabolism is now provided by Yoo et al., identifying the mitochondrial glutamine importer as a variant of SLC1A5.",

keywords = "alternative promoter, glutamine, hypoxia, metabolism, mitochondria, transporter",

author = "Stine, {Zachary E.} and Dang, {Chi V.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2020",

month = jan,

doi = "10.1016/j.molmed.2019.11.004",

language = "English (US)",

volume = "26",

pages = "6--7",

journal = "Trends in Molecular Medicine",

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T1 - Glutamine Skipping the Q into Mitochondria

AU - Stine, Zachary E.

AU - Dang, Chi V.

PY - 2020/1

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N2 - Imported across the plasma membrane by SLC1A5, glutamine has emerged as a metabolic fuel that is catabolized by mitochondrial glutaminase to support tumor growth. The missing link between cytoplasmic and mitochondrial glutamine metabolism is now provided by Yoo et al., identifying the mitochondrial glutamine importer as a variant of SLC1A5.

AB - Imported across the plasma membrane by SLC1A5, glutamine has emerged as a metabolic fuel that is catabolized by mitochondrial glutaminase to support tumor growth. The missing link between cytoplasmic and mitochondrial glutamine metabolism is now provided by Yoo et al., identifying the mitochondrial glutamine importer as a variant of SLC1A5.

KW - alternative promoter

KW - glutamine

KW - hypoxia

KW - metabolism

KW - mitochondria

KW - transporter

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U2 - 10.1016/j.molmed.2019.11.004

DO - 10.1016/j.molmed.2019.11.004

M3 - Short survey

C2 - 31866300

AN - SCOPUS:85076901577

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EP - 7

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 1

ER -

Glutamine Skipping the Q into Mitochondria

Abstract

Keywords

ASJC Scopus subject areas

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