Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques

Lary C. Walker; Cheryl A. Kitt; Robert G. Struble; Donald E. Schmechel; Wolfgang H. Oertel; Linda C. Cork; Donald L. Price

doi:10.1016/0304-3940(85)90194-6

Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques

Lary C. Walker, Cheryl A. Kitt, Robert G. Struble, Donald E. Schmechel, Wolfgang H. Oertel, Linda C. Cork, Donald L. Price

School of Medicine

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

In the neocortex of an aged (26-year-old) rhesus monkey, a small percentage of abnormal neurites within some senile plaques (defined by the presence of amyloid) were immunoreactive for glutamic acid decarboxylase. This suggests that γ-aminobutyric acid-synthesizing neurons may contribute to plaque formation in the aged brain.

Original language	English (US)
Pages (from-to)	165-169
Number of pages	5
Journal	Neuroscience Letters
Volume	59
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(85)90194-6
State	Published - Aug 30 1985

Keywords

aging
Alzheimer's disease
glutamic acid decarboxylase
immunocytochemistry
monkey
senile plaque

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(85)90194-6

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title = "Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques",

abstract = "In the neocortex of an aged (26-year-old) rhesus monkey, a small percentage of abnormal neurites within some senile plaques (defined by the presence of amyloid) were immunoreactive for glutamic acid decarboxylase. This suggests that γ-aminobutyric acid-synthesizing neurons may contribute to plaque formation in the aged brain.",

keywords = "aging, Alzheimer's disease, glutamic acid decarboxylase, immunocytochemistry, monkey, senile plaque",

author = "Walker, {Lary C.} and Kitt, {Cheryl A.} and Struble, {Robert G.} and Schmechel, {Donald E.} and Oertel, {Wolfgang H.} and Cork, {Linda C.} and Price, {Donald L.}",

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T1 - Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques

AU - Walker, Lary C.

AU - Kitt, Cheryl A.

AU - Struble, Robert G.

AU - Schmechel, Donald E.

AU - Oertel, Wolfgang H.

AU - Cork, Linda C.

AU - Price, Donald L.

PY - 1985/8/30

Y1 - 1985/8/30

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AB - In the neocortex of an aged (26-year-old) rhesus monkey, a small percentage of abnormal neurites within some senile plaques (defined by the presence of amyloid) were immunoreactive for glutamic acid decarboxylase. This suggests that γ-aminobutyric acid-synthesizing neurons may contribute to plaque formation in the aged brain.

KW - aging

KW - Alzheimer's disease

KW - glutamic acid decarboxylase

KW - immunocytochemistry

KW - monkey

KW - senile plaque

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques

Abstract

Keywords

ASJC Scopus subject areas

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