Glutamate recognition sites in human fetal brain

John D. Barks; Faye S. Silverstein; Katherine Sims; J. Timothy Greenamyre; Michael V. Johnston

doi:10.1016/0304-3940(88)90396-5

Glutamate recognition sites in human fetal brain

John D. Barks, Faye S. Silverstein, Katherine Sims, J. Timothy Greenamyre, Michael V. Johnston

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

We used in vitro autoradiography with [³H]glutamate to examine the distribution of glutamate recognition sites in 18 and 21 week gestation human fetal brains. We found a wide distribution of [³H]glutamate binding in both specimens, in a pattern distinct from that reported in adult brain using the same autoradiographic methods. In fetal brain, prominent [³H]glutamate binding was evident in hippocampal formation, caudate-putamen, globus pallidus, subthalamic nucleus, reticular nucleus of thalamus and substantia innominata.

Original language	English (US)
Pages (from-to)	131-136
Number of pages	6
Journal	Neuroscience Letters
Volume	84
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(88)90396-5
State	Published - Jan 22 1988
Externally published	Yes

Keywords

Autoradiography
Caudate
Fetus
Globus pallidus
Glutamate
Hippocampus
Human

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(88)90396-5

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title = "Glutamate recognition sites in human fetal brain",

abstract = "We used in vitro autoradiography with [3H]glutamate to examine the distribution of glutamate recognition sites in 18 and 21 week gestation human fetal brains. We found a wide distribution of [3H]glutamate binding in both specimens, in a pattern distinct from that reported in adult brain using the same autoradiographic methods. In fetal brain, prominent [3H]glutamate binding was evident in hippocampal formation, caudate-putamen, globus pallidus, subthalamic nucleus, reticular nucleus of thalamus and substantia innominata.",

keywords = "Autoradiography, Caudate, Fetus, Globus pallidus, Glutamate, Hippocampus, Human",

author = "Barks, {John D.} and Silverstein, {Faye S.} and Katherine Sims and Greenamyre, {J. Timothy} and Johnston, {Michael V.}",

note = "Funding Information: A preliminarrye porto f thesed atawas presenteadt the annualm eetingo f the Child NeurologyS ocietyB, oston,1 986T. his work was supporteidn part by PHS Grant 1 POI NS 19613(M .V.J.) and 1 KO8 NSO1171 (F.S.S.).",

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doi = "10.1016/0304-3940(88)90396-5",

language = "English (US)",

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journal = "Neuroscience Letters",

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TY - JOUR

T1 - Glutamate recognition sites in human fetal brain

AU - Barks, John D.

AU - Silverstein, Faye S.

AU - Sims, Katherine

AU - Greenamyre, J. Timothy

AU - Johnston, Michael V.

N1 - Funding Information: A preliminarrye porto f thesed atawas presenteadt the annualm eetingo f the Child NeurologyS ocietyB, oston,1 986T. his work was supporteidn part by PHS Grant 1 POI NS 19613(M .V.J.) and 1 KO8 NSO1171 (F.S.S.).

PY - 1988/1/22

Y1 - 1988/1/22

N2 - We used in vitro autoradiography with [3H]glutamate to examine the distribution of glutamate recognition sites in 18 and 21 week gestation human fetal brains. We found a wide distribution of [3H]glutamate binding in both specimens, in a pattern distinct from that reported in adult brain using the same autoradiographic methods. In fetal brain, prominent [3H]glutamate binding was evident in hippocampal formation, caudate-putamen, globus pallidus, subthalamic nucleus, reticular nucleus of thalamus and substantia innominata.

AB - We used in vitro autoradiography with [3H]glutamate to examine the distribution of glutamate recognition sites in 18 and 21 week gestation human fetal brains. We found a wide distribution of [3H]glutamate binding in both specimens, in a pattern distinct from that reported in adult brain using the same autoradiographic methods. In fetal brain, prominent [3H]glutamate binding was evident in hippocampal formation, caudate-putamen, globus pallidus, subthalamic nucleus, reticular nucleus of thalamus and substantia innominata.

KW - Autoradiography

KW - Caudate

KW - Fetus

KW - Globus pallidus

KW - Glutamate

KW - Hippocampus

KW - Human

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SP - 131

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Glutamate recognition sites in human fetal brain

Abstract

Keywords

ASJC Scopus subject areas

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