Background: Hypothalamic long-chain fatty acids (LCFA) and glucose are critical for energy balance, but it is not known if their metabolism is coupled. Results: Glucose regulates hypothalamic metabolism of palmitate via AMP-activated kinase. Conclusion: Glucose and LCFA metabolism is coupled in a cell-type and LCFA-dependent manner. Significance: This is the first evidence for glucose regulation of LCFA metabolic fate in the hypothalamus.
|Original language||English (US)|
|Number of pages||14|
|Journal||Journal of Biological Chemistry|
|State||Published - Dec 27 2013|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology