Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes

Angelo Scuteri; Christopher H. Morrell; Majd AlGhatrif; Marco Orru; Edoardo Fiorillo; Michele Marongiu; David Schlessinger; Francesco Cucca; Edward G. Lakatta

doi:10.1007/s00592-023-02118-8

Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes

Angelo Scuteri, Christopher H. Morrell, Majd AlGhatrif, Marco Orru, Edoardo Fiorillo, Michele Marongiu, David Schlessinger, Francesco Cucca, Edward G. Lakatta

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Aims: High glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes. Methods: Plasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population. Results: Although high plasma glucose in diabetics, did not differ by G6DP status (178.2 ± 55.1 vs 169.0 ± 50.1 mg/dl) in G6DPd versus non-G6PDd subjects, respectively, IL6, and PWV (adjusted for age and glucose) were significantly increased in G6PDd vs non-G6PDd subjects (PWV, 8.0 ± 0.4 vs 7.2 ± 0.2 m/sec) and (IL6, 6.9 ± 5.0 vs 4.2 ± 3.0 pg/ml). In non-diabetics, neither fasting plasma glucose, nor IL6, nor PWV were impacted by G6PDd. Conclusion: G6PDd in diabetics is associated with increased inflammatory markers and accelerated arterial aging.

Original language	English (US)
Pages (from-to)	127-130
Number of pages	4
Journal	Acta Diabetologica
Volume	61
Issue number	1
DOIs	https://doi.org/10.1007/s00592-023-02118-8
State	Published - Jan 2024

Keywords

Aging
Arterial stiffness
Diabetes
Glucose 5 phosphate dehydrogenase
Interleukin 6
Pulse wave velocity

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1007/s00592-023-02118-8

Cite this

@article{bd326c7568ad436589e5fda3f49ea7c6,

title = "Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes",

abstract = "Aims: High glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes. Methods: Plasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population. Results: Although high plasma glucose in diabetics, did not differ by G6DP status (178.2 ± 55.1 vs 169.0 ± 50.1 mg/dl) in G6DPd versus non-G6PDd subjects, respectively, IL6, and PWV (adjusted for age and glucose) were significantly increased in G6PDd vs non-G6PDd subjects (PWV, 8.0 ± 0.4 vs 7.2 ± 0.2 m/sec) and (IL6, 6.9 ± 5.0 vs 4.2 ± 3.0 pg/ml). In non-diabetics, neither fasting plasma glucose, nor IL6, nor PWV were impacted by G6PDd. Conclusion: G6PDd in diabetics is associated with increased inflammatory markers and accelerated arterial aging.",

keywords = "Aging, Arterial stiffness, Diabetes, Glucose 5 phosphate dehydrogenase, Interleukin 6, Pulse wave velocity",

author = "Angelo Scuteri and Morrell, {Christopher H.} and Majd AlGhatrif and Marco Orru and Edoardo Fiorillo and Michele Marongiu and David Schlessinger and Francesco Cucca and Lakatta, {Edward G.}",

note = "Publisher Copyright: {\textcopyright} This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023.",

year = "2024",

month = jan,

doi = "10.1007/s00592-023-02118-8",

language = "English (US)",

volume = "61",

pages = "127--130",

journal = "Acta Diabetologica",

issn = "0940-5429",

publisher = "Springer-Verlag Italia s.r.l.",

number = "1",

}

TY - JOUR

T1 - Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes

AU - Scuteri, Angelo

AU - Morrell, Christopher H.

AU - AlGhatrif, Majd

AU - Orru, Marco

AU - Fiorillo, Edoardo

AU - Marongiu, Michele

AU - Schlessinger, David

AU - Cucca, Francesco

AU - Lakatta, Edward G.

N1 - Publisher Copyright: © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023.

PY - 2024/1

Y1 - 2024/1

N2 - Aims: High glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes. Methods: Plasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population. Results: Although high plasma glucose in diabetics, did not differ by G6DP status (178.2 ± 55.1 vs 169.0 ± 50.1 mg/dl) in G6DPd versus non-G6PDd subjects, respectively, IL6, and PWV (adjusted for age and glucose) were significantly increased in G6PDd vs non-G6PDd subjects (PWV, 8.0 ± 0.4 vs 7.2 ± 0.2 m/sec) and (IL6, 6.9 ± 5.0 vs 4.2 ± 3.0 pg/ml). In non-diabetics, neither fasting plasma glucose, nor IL6, nor PWV were impacted by G6PDd. Conclusion: G6PDd in diabetics is associated with increased inflammatory markers and accelerated arterial aging.

AB - Aims: High glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes. Methods: Plasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population. Results: Although high plasma glucose in diabetics, did not differ by G6DP status (178.2 ± 55.1 vs 169.0 ± 50.1 mg/dl) in G6DPd versus non-G6PDd subjects, respectively, IL6, and PWV (adjusted for age and glucose) were significantly increased in G6PDd vs non-G6PDd subjects (PWV, 8.0 ± 0.4 vs 7.2 ± 0.2 m/sec) and (IL6, 6.9 ± 5.0 vs 4.2 ± 3.0 pg/ml). In non-diabetics, neither fasting plasma glucose, nor IL6, nor PWV were impacted by G6PDd. Conclusion: G6PDd in diabetics is associated with increased inflammatory markers and accelerated arterial aging.

KW - Aging

KW - Arterial stiffness

KW - Diabetes

KW - Glucose 5 phosphate dehydrogenase

KW - Interleukin 6

KW - Pulse wave velocity

UR - http://www.scopus.com/inward/record.url?scp=85171999356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85171999356&partnerID=8YFLogxK

U2 - 10.1007/s00592-023-02118-8

DO - 10.1007/s00592-023-02118-8

M3 - Article

C2 - 37741911

AN - SCOPUS:85171999356

SN - 0940-5429

VL - 61

SP - 127

EP - 130

JO - Acta Diabetologica

JF - Acta Diabetologica

IS - 1

ER -

Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this