Glucose-6-phosphate dehydrogenase and the histogenesis of epidermoid carcinoma of the cervix

In Joo Park; Howard W. Jones

doi:10.1016/0002-9378(68)90439-0

Glucose-6-phosphate dehydrogenase and the histogenesis of epidermoid carcinoma of the cervix

In Joo Park, Howard W. Jones

School of Medicine

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26 Scopus citations

Abstract

The result of vertical starch gel electrophoresis of blood, cancerous, and noncancerous epithelium of the cervix of 18 patients who were heterozygous for G-6-PD variants is presented. Among 10 patients without cancer of the cervix, examination of the cervical epithelium showed 9 with 2 bands and one with 1 band. Among 8 patients with cancer, examination of the cancer tissue showed 5 with a single band (1A and 4B) and 3 with double bands. It is proposed that the evidence is consistent with the concept that epidermoid carcinoma of the cervix arises from a single cell. It is also concluded that the Lyon phenomenon is also functioning in at least some tumors.

Original language	English (US)
Pages (from-to)	106-109
Number of pages	4
Journal	American journal of obstetrics and gynecology
Volume	102
Issue number	1
DOIs	https://doi.org/10.1016/0002-9378(68)90439-0
State	Published - Sep 1 1968

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/0002-9378(68)90439-0

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title = "Glucose-6-phosphate dehydrogenase and the histogenesis of epidermoid carcinoma of the cervix",

abstract = "The result of vertical starch gel electrophoresis of blood, cancerous, and noncancerous epithelium of the cervix of 18 patients who were heterozygous for G-6-PD variants is presented. Among 10 patients without cancer of the cervix, examination of the cervical epithelium showed 9 with 2 bands and one with 1 band. Among 8 patients with cancer, examination of the cancer tissue showed 5 with a single band (1A and 4B) and 3 with double bands. It is proposed that the evidence is consistent with the concept that epidermoid carcinoma of the cervix arises from a single cell. It is also concluded that the Lyon phenomenon is also functioning in at least some tumors.",

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note = "Funding Information: From the Department of Gynecology and Obstetrics, The ,johns Hopkins University School of Medicine. Aided by Grant No. T-426, American Cancer Society. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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N2 - The result of vertical starch gel electrophoresis of blood, cancerous, and noncancerous epithelium of the cervix of 18 patients who were heterozygous for G-6-PD variants is presented. Among 10 patients without cancer of the cervix, examination of the cervical epithelium showed 9 with 2 bands and one with 1 band. Among 8 patients with cancer, examination of the cancer tissue showed 5 with a single band (1A and 4B) and 3 with double bands. It is proposed that the evidence is consistent with the concept that epidermoid carcinoma of the cervix arises from a single cell. It is also concluded that the Lyon phenomenon is also functioning in at least some tumors.

AB - The result of vertical starch gel electrophoresis of blood, cancerous, and noncancerous epithelium of the cervix of 18 patients who were heterozygous for G-6-PD variants is presented. Among 10 patients without cancer of the cervix, examination of the cervical epithelium showed 9 with 2 bands and one with 1 band. Among 8 patients with cancer, examination of the cancer tissue showed 5 with a single band (1A and 4B) and 3 with double bands. It is proposed that the evidence is consistent with the concept that epidermoid carcinoma of the cervix arises from a single cell. It is also concluded that the Lyon phenomenon is also functioning in at least some tumors.

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Glucose-6-phosphate dehydrogenase and the histogenesis of epidermoid carcinoma of the cervix

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