Glucose-6-phosphate dehydrogenase and the histogenesis of epidermoid carcinoma of the cervix

In Joo Park, Howard W. Jones

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The result of vertical starch gel electrophoresis of blood, cancerous, and noncancerous epithelium of the cervix of 18 patients who were heterozygous for G-6-PD variants is presented. Among 10 patients without cancer of the cervix, examination of the cervical epithelium showed 9 with 2 bands and one with 1 band. Among 8 patients with cancer, examination of the cancer tissue showed 5 with a single band (1A and 4B) and 3 with double bands. It is proposed that the evidence is consistent with the concept that epidermoid carcinoma of the cervix arises from a single cell. It is also concluded that the Lyon phenomenon is also functioning in at least some tumors.

Original languageEnglish (US)
Pages (from-to)106-109
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Issue number1
StatePublished - Sep 1 1968

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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