Globus pallidus volume is related to symptom severity in neuroleptic naive patients with schizophrenia

Ruth Spinks; Peg Nopoulos; Julie Ward; Rebecca Fuller; Vincent A. Magnotta; Nancy C. Andreasen

doi:10.1016/j.schres.2004.05.020

Globus pallidus volume is related to symptom severity in neuroleptic naive patients with schizophrenia

Ruth Spinks, Peg Nopoulos, Julie Ward, Rebecca Fuller, Vincent A. Magnotta, Nancy C. Andreasen

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

This study compares globus pallidus (GP) volume between neuroleptic naïve patients with schizophrenia and healthy controls using structural MRI. The volume of the external segment of the GP (GPe) was positively correlated with the severity of global symptoms, as measured by the Scale for the Assessment of Negative Symptoms and Scale for the Assessment of Positive Symptoms (SANS/SAPS, Andreasen and Olsen, 1982). The volume for the GP, GPe, and internal segment (GPi) did not differ between groups.

Original language	English (US)
Pages (from-to)	229-233
Number of pages	5
Journal	Schizophrenia Research
Volume	73
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2004.05.020
State	Published - Mar 1 2005
Externally published	Yes

Keywords

Globus pallidus
MRI
Neuroleptic naïve
Subcortical structures
Symptom severity

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2004.05.020

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title = "Globus pallidus volume is related to symptom severity in neuroleptic naive patients with schizophrenia",

abstract = "This study compares globus pallidus (GP) volume between neuroleptic na{\"i}ve patients with schizophrenia and healthy controls using structural MRI. The volume of the external segment of the GP (GPe) was positively correlated with the severity of global symptoms, as measured by the Scale for the Assessment of Negative Symptoms and Scale for the Assessment of Positive Symptoms (SANS/SAPS, Andreasen and Olsen, 1982). The volume for the GP, GPe, and internal segment (GPi) did not differ between groups.",

keywords = "Globus pallidus, MRI, Neuroleptic na{\"i}ve, Subcortical structures, Symptom severity",

author = "Ruth Spinks and Peg Nopoulos and Julie Ward and Rebecca Fuller and Magnotta, {Vincent A.} and Andreasen, {Nancy C.}",

note = "Funding Information: This research was supported by NIMH Grants #8910494, #8103070, and #98010017. Dr. Spinks was also supported by a grant from the Nellie Ball Trust for Schizophrenia Research.",

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AU - Spinks, Ruth

AU - Nopoulos, Peg

AU - Ward, Julie

AU - Fuller, Rebecca

AU - Magnotta, Vincent A.

AU - Andreasen, Nancy C.

N1 - Funding Information: This research was supported by NIMH Grants #8910494, #8103070, and #98010017. Dr. Spinks was also supported by a grant from the Nellie Ball Trust for Schizophrenia Research.

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N2 - This study compares globus pallidus (GP) volume between neuroleptic naïve patients with schizophrenia and healthy controls using structural MRI. The volume of the external segment of the GP (GPe) was positively correlated with the severity of global symptoms, as measured by the Scale for the Assessment of Negative Symptoms and Scale for the Assessment of Positive Symptoms (SANS/SAPS, Andreasen and Olsen, 1982). The volume for the GP, GPe, and internal segment (GPi) did not differ between groups.

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KW - Globus pallidus

KW - MRI

KW - Neuroleptic naïve

KW - Subcortical structures

KW - Symptom severity

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Globus pallidus volume is related to symptom severity in neuroleptic naive patients with schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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