TY - JOUR
T1 - Global Unmet Needs in Cardiac Surgery
AU - Zilla, Peter
AU - Yacoub, Magdi
AU - Zühlke, Liesl
AU - Beyersdorf, Friedhelm
AU - Sliwa, Karen
AU - Khubulava, Gennadiy
AU - Bouzid, Abdelmalek
AU - Mocumbi, Ana Olga
AU - Velayoudam, Devagourou
AU - Shetty, Devi
AU - Ofoegbu, Chima
AU - Geldenhuys, Agneta
AU - Brink, Johan
AU - Scherman, Jacques
AU - du Toit, Henning
AU - Hosseini, Saeid
AU - Zhang, Hao
AU - Luo, Xin Jin
AU - Wang, Wei
AU - Mejia, Juan
AU - Kofidis, Theodoros
AU - Higgins, Robert S.D.
AU - Pomar, Jose
AU - Bolman, R. Morton
AU - Mayosi, Bongani M.
AU - Madansein, Rajhmun
AU - Bavaria, Joseph
AU - Yanes-Quintana, Alberto A.
AU - Kumar, A. Sampath
AU - Adeoye, Oladapo
AU - Chauke, Risenga Frank
AU - Williams, David F.
N1 - Funding Information:
This study was partially supported by the South African National Research Foundation (NRF) through the grant for rated scientists.
Funding Information:
HIC are past their epidemiological transition and have developed well-established cardiac surgical services that largely cover their population's needs. As such, their known prevalence of adult and pediatric cardiac operations as well as their patterns of underlying pathologies can be seen as a contemporary saturation point of an industrialized society. LIC, in contrast, are largely in a pre-epidemiological transition phase, and as such, needs are very different from those of industrialized countries. Although it is an acknowledged fact that the two main pathologies requiring cardiac surgery in LIC are congenital cardiac defects and RHD, estimates have been vague and largely based on echocardiographic screening studies [35] . Recent global and regional epidemiological studies have, for the first time, correlated the prevalence of silent rheumatic valvular disease with that of cardiac failure and death caused by the disease allowing conservative estimates of the need for cardiac surgery for RHD. Although these indirect deductions will remain estimates until such time when well-established cardiac services provide firm data, they for the first time allow an approximate assessment of two core questions: how many cardiac operations should one expect to be needed in an LIC per million population and how much do the needs for cardiac surgery differ between a pre-transition LIC and a post-transition HIC. Conservatively narrowing the range to 100 to 300 operations per million population for LIC highlighted the fact that the gradual disappearance of rheumatic heart RHD with affluence and its replacement with degenerative/lifestyle diseases will translate into a 4 to 5 times higher need for cardiac surgery once the epidemiological transition has been concluded ( Figure 4 ). This assumes today's circumstances continue to apply and does not take lifestyle changes and future preventive pharmacotherapies and other strategies into account. An estimated ratio of 3 to 5:1 of RHD to CHD also allows investigators to assign a rough numeric value to the often less visible needs of rheumatic patients in LIC against the background of children's needs. Last but not least, MIC have made impressive strides toward provision of cardiac surgical services in the recent past. The simultaneous presence of RHD and degenerative/lifestyle diseases in these countries allows at least an informed guesstimate of where the cardiac surgical needs of the population on the epidemiological transition scale from 100 to 1,200 per million may lie. Our multi-author attempt to define the national status of open heart surgery in 1 LIC, 4 lower-middle income countries, 8 upper-middle-income countries, and 2 HIC does not claim to accurately represent the situation in all comparable countries. It does, however, allow a very critical comparison of key parameters based on major representatives in each group. In the short run it may provide guidance for governments and nongovernmental organizations in LIC while also helping to predict the medium-term to long-term developments in MIC. This study was partially supported by the South African National Research Foundation (NRF) through the grant for rated scientists.
Publisher Copyright:
© 2018 The Authors
PY - 2018/12
Y1 - 2018/12
N2 - More than 6 billion people live outside industrialized countries and have insufficient access to cardiac surgery. Given the recently confirmed high prevailing mortality for rheumatic heart disease in many of these countries together with increasing numbers of patients needing interventions for lifestyle diseases due to an accelerating epidemiological transition, a significant need for cardiac surgery could be assumed. Yet, need estimates were largely based on extrapolated screening studies while true service levels remained unknown. A multi-author effort representing 16 high-, middle-, and low-income countries was undertaken to narrow the need assessment for cardiac surgery including rheumatic and lifestyle cardiac diseases as well as congenital heart disease on the basis of existing data deduction. Actual levels of cardiac surgery were determined in each of these countries on the basis of questionnaires, national databases, or annual reports of national societies. Need estimates range from 200 operations per million in low-income countries that are nonendemic for rheumatic heart disease to >1,000 operations per million in high-income countries representing the end of the epidemiological transition. Actually provided levels of cardiac surgery range from 0.5 per million in the assessed low- and lower-middle income countries (average 107 ± 113 per million; representing a population of 1.6 billion) to 500 in the upper-middle-income countries (average 270 ± 163 per million representing a population of 1.9 billion). By combining need estimates with the assessment of de facto provided levels of cardiac surgery, it emerged that a significant degree of underdelivery of often lifesaving open heart surgery does not only prevail in low-income countries but is also disturbingly high in middle-income countries.
AB - More than 6 billion people live outside industrialized countries and have insufficient access to cardiac surgery. Given the recently confirmed high prevailing mortality for rheumatic heart disease in many of these countries together with increasing numbers of patients needing interventions for lifestyle diseases due to an accelerating epidemiological transition, a significant need for cardiac surgery could be assumed. Yet, need estimates were largely based on extrapolated screening studies while true service levels remained unknown. A multi-author effort representing 16 high-, middle-, and low-income countries was undertaken to narrow the need assessment for cardiac surgery including rheumatic and lifestyle cardiac diseases as well as congenital heart disease on the basis of existing data deduction. Actual levels of cardiac surgery were determined in each of these countries on the basis of questionnaires, national databases, or annual reports of national societies. Need estimates range from 200 operations per million in low-income countries that are nonendemic for rheumatic heart disease to >1,000 operations per million in high-income countries representing the end of the epidemiological transition. Actually provided levels of cardiac surgery range from 0.5 per million in the assessed low- and lower-middle income countries (average 107 ± 113 per million; representing a population of 1.6 billion) to 500 in the upper-middle-income countries (average 270 ± 163 per million representing a population of 1.9 billion). By combining need estimates with the assessment of de facto provided levels of cardiac surgery, it emerged that a significant degree of underdelivery of often lifesaving open heart surgery does not only prevail in low-income countries but is also disturbingly high in middle-income countries.
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U2 - 10.1016/j.gheart.2018.08.002
DO - 10.1016/j.gheart.2018.08.002
M3 - Review article
C2 - 30245177
AN - SCOPUS:85053626467
SN - 2211-8160
VL - 13
SP - 293
EP - 303
JO - CVD Prevention and Control
JF - CVD Prevention and Control
IS - 4
ER -