Global Assessment Variables

Barbara C. Tilley, Peng Huang, Peter C. O'Brien

Research output: Chapter in Book/Report/Conference proceedingChapter


Global statistical tests (GSTs) and associated global treatment effects (GTEs) summarize a treatment's global benefit without the need of performing multiple univariate tests for individual outcomes. This chapter discusses different versions of GSTs. Some of the GST's discussed in the chapter include: rank-sum-type GST; adjusted rank-sum-type GST; likelihood ratio (LR)-Based GST; and Follmann's GST. The main rationale for using a global outcome in a clinical trial is that, by providing a more comprehensive and thus more informative assessment of the patient, it also provides a more clinically meaningful primary endpoint than use of any single variable by itself. Two other approaches for using multiple endpoints in the primary analysis of a clinical trial are the T2 statistic and use of multiple comparison procedures.

Original languageEnglish (US)
Title of host publicationConcepts, Principles, Trials, and Designs
Number of pages15
ISBN (Electronic)9781118596005
ISBN (Print)9781118595923
StatePublished - Sep 26 2014


  • Clinical trial
  • Global assessment variables
  • Global statistical tests (GSTs)
  • Global treatment effects (GTEs)

ASJC Scopus subject areas

  • Medicine(all)


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