Global analysis of protein function using protein microarrays

Michael G. Smith, Ghil Jona, Jason Ptacek, Geeta Devgan, Heng Zhu, Xiaowei Zhu, Michael Snyder

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Protein microarrays containing thousands of proteins arrayed at high density can be prepared and probed for a wide variety of activities, thereby allowing the large scale analysis of many proteins simultaneously. In addition to identifying the activities of many previously uncharacterized proteins, protein microarrays can reveal new activities of well-characterized proteins, thus providing new insights about the functions of these proteins. Below, we describe the construction and use of protein microarrays and their applications using yeast as a model system.

Original languageEnglish (US)
Pages (from-to)171-175
Number of pages5
JournalMechanisms of Ageing and Development
Issue number1
StatePublished - Jan 2005


  • Discovery research
  • Genome
  • High-throughput
  • Microarrays
  • Proteomics

ASJC Scopus subject areas

  • Aging
  • Developmental Biology


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