Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Patrick Y. Wen; Michael Weller; Eudocia Quant Lee; Brian M. Alexander; Jill S. Barnholtz-Sloan; Floris P. Barthel; Tracy T. Batchelor; Ranjit S. Bindra; Susan M. Chang; E. Antonio Chiocca; Timothy F. Cloughesy; John F. DeGroot; Evanthia Galanis; Mark R. Gilbert; Monika E. Hegi; Craig Horbinski; Raymond Y. Huang; Andrew B. Lassman; Emilie Le Rhun; Michael Lim; Minesh P. Mehta; Ingo K. Mellinghoff; Giuseppe Minniti; David Nathanson; Michael Platten; Matthias Preusser; Patrick Roth; Marc Sanson; David Schiff; Susan C. Short; Martin J.B. Taphoorn; Joerg Christian Tonn; Jonathan Tsang; Roel G.W. Verhaak; Andreas von Deimling; Wolfgang Wick; Gelareh Zadeh; David A. Reardon; Kenneth D. Aldape; Martin J. van den Bent

doi:10.1093/neuonc/noaa106

Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Patrick Y. Wen, Michael Weller, Eudocia Quant Lee, Brian M. Alexander, Jill S. Barnholtz-Sloan, Floris P. Barthel, Tracy T. Batchelor, Ranjit S. Bindra, Susan M. Chang, E. Antonio Chiocca, Timothy F. Cloughesy, John F. DeGroot, Evanthia Galanis, Mark R. Gilbert, Monika E. Hegi, Craig Horbinski, Raymond Y. Huang, Andrew B. Lassman, Emilie Le Rhun, Michael LimMinesh P. Mehta, Ingo K. Mellinghoff, Giuseppe Minniti, David Nathanson, Michael Platten, Matthias Preusser, Patrick Roth, Marc Sanson, David Schiff, Susan C. Short, Martin J.B. Taphoorn, Joerg Christian Tonn, Jonathan Tsang, Roel G.W. Verhaak, Andreas von Deimling, Wolfgang Wick, Gelareh Zadeh, David A. Reardon, Kenneth D. Aldape, Martin J. van den Bent

School of Medicine

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.

Original language	English (US)
Pages (from-to)	1073-1113
Number of pages	41
Journal	Neuro-oncology
Volume	22
Issue number	8
DOIs	https://doi.org/10.1093/neuonc/noaa106
State	Published - Aug 1 2020

Keywords

Clinical trials
Diagnosis
Glioblastoma
Therapy

ASJC Scopus subject areas

Oncology
Clinical Neurology
Cancer Research

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10.1093/neuonc/noaa106

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Wen, P. Y., Weller, M., Lee, E. Q., Alexander, B. M., Barnholtz-Sloan, J. S., Barthel, F. P., Batchelor, T. T., Bindra, R. S., Chang, S. M., Antonio Chiocca, E., Cloughesy, T. F., DeGroot, J. F., Galanis, E., Gilbert, M. R., Hegi, M. E., Horbinski, C., Huang, R. Y., Lassman, A. B., Le Rhun, E., ... van den Bent, M. J. (2020). Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro-oncology, 22(8), 1073-1113. https://doi.org/10.1093/neuonc/noaa106

Wen, PY, Weller, M, Lee, EQ, Alexander, BM, Barnholtz-Sloan, JS, Barthel, FP, Batchelor, TT, Bindra, RS, Chang, SM, Antonio Chiocca, E, Cloughesy, TF, DeGroot, JF, Galanis, E, Gilbert, MR, Hegi, ME, Horbinski, C, Huang, RY, Lassman, AB, Le Rhun, E, Lim, M, Mehta, MP, Mellinghoff, IK, Minniti, G, Nathanson, D, Platten, M, Preusser, M, Roth, P, Sanson, M, Schiff, D, Short, SC, Taphoorn, MJB, Tonn, JC, Tsang, J, Verhaak, RGW, von Deimling, A, Wick, W, Zadeh, G, Reardon, DA, Aldape, KD & van den Bent, MJ 2020, 'Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions', Neuro-oncology, vol. 22, no. 8, pp. 1073-1113. https://doi.org/10.1093/neuonc/noaa106

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title = "Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions",

abstract = "Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.",

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author = "Wen, {Patrick Y.} and Michael Weller and Lee, {Eudocia Quant} and Alexander, {Brian M.} and Barnholtz-Sloan, {Jill S.} and Barthel, {Floris P.} and Batchelor, {Tracy T.} and Bindra, {Ranjit S.} and Chang, {Susan M.} and {Antonio Chiocca}, E. and Cloughesy, {Timothy F.} and DeGroot, {John F.} and Evanthia Galanis and Gilbert, {Mark R.} and Hegi, {Monika E.} and Craig Horbinski and Huang, {Raymond Y.} and Lassman, {Andrew B.} and {Le Rhun}, Emilie and Michael Lim and Mehta, {Minesh P.} and Mellinghoff, {Ingo K.} and Giuseppe Minniti and David Nathanson and Michael Platten and Matthias Preusser and Patrick Roth and Marc Sanson and David Schiff and Short, {Susan C.} and Taphoorn, {Martin J.B.} and Tonn, {Joerg Christian} and Jonathan Tsang and Verhaak, {Roel G.W.} and {von Deimling}, Andreas and Wolfgang Wick and Gelareh Zadeh and Reardon, {David A.} and Aldape, {Kenneth D.} and {van den Bent}, {Martin J.}",

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doi = "10.1093/neuonc/noaa106",

language = "English (US)",

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AU - Weller, Michael

AU - Lee, Eudocia Quant

AU - Alexander, Brian M.

AU - Barnholtz-Sloan, Jill S.

AU - Barthel, Floris P.

AU - Batchelor, Tracy T.

AU - Bindra, Ranjit S.

AU - Chang, Susan M.

AU - Antonio Chiocca, E.

AU - Cloughesy, Timothy F.

AU - DeGroot, John F.

AU - Galanis, Evanthia

AU - Gilbert, Mark R.

AU - Hegi, Monika E.

AU - Horbinski, Craig

AU - Huang, Raymond Y.

AU - Lassman, Andrew B.

AU - Le Rhun, Emilie

AU - Lim, Michael

AU - Mehta, Minesh P.

AU - Mellinghoff, Ingo K.

AU - Minniti, Giuseppe

AU - Nathanson, David

AU - Platten, Michael

AU - Preusser, Matthias

AU - Roth, Patrick

AU - Sanson, Marc

AU - Schiff, David

AU - Short, Susan C.

AU - Taphoorn, Martin J.B.

AU - Tonn, Joerg Christian

AU - Tsang, Jonathan

AU - Verhaak, Roel G.W.

AU - von Deimling, Andreas

AU - Wick, Wolfgang

AU - Zadeh, Gelareh

AU - Reardon, David A.

AU - Aldape, Kenneth D.

AU - van den Bent, Martin J.

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N2 - Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.

AB - Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.

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KW - Diagnosis

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KW - Therapy

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Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Abstract

Keywords

ASJC Scopus subject areas

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