Glial shape and cytoskeletal protein synthesis

Joseph P. Bressler, Nancy A. Edwards

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We investigated whether the shape of astroglial derived cells influences the expression of cytoskeletal proteins. In reaggregating cultures GFAP, vimentin and actin synthesis was approximately 52%, 50% and 37% the level found in monolayer cultures, respectively. Monolayer cultures consisted of polygonal shaped cells adhering to plastic, while reaggregating cultures were comprised of round cells growing in a suspension like culture. Additionally, human glioma cells induced to grow as round cells on poly-2-hydroxyethyl methacrylate (polyhema) coated plastic exhibited a level of GFAP synthesis that was approximately 20% the level displayed by polygonal shaped cells grown on uncoated plastic. Glioma cells initially grown on a polyhema surface and replated onto uncoated plastic were capable of reinitiating GFAP synthesis. Thus, aterations in the synthesis of GFAP and other cytoskeletal proteins can occur when astrocytes change their shape.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalNeurochemical Research
Issue number2
StatePublished - Feb 1992


  • Shape
  • astrocyte
  • glioma
  • intermediary filament

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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