Gestational weight gain in women with polycystic ovary syndrome: A controlled study

James Kent, William C. Dodson, Allen Kunselman, Jaimey Pauli, Alicia Stone, Michael P. Diamond, Christos Coutifaris, William D. Schlaff, Ruben Alvero, Peter Casson, Gregory M. Christman, R. Mitchell Rosen, Karl R. Hansen, Randall D. Robinson, Valerie Baker, Rebecca Usadi, Nanette Santoro, Heping Zhang, Esther Eisenberg, Richard S. Legro

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Context: Women with polycystic ovary syndrome (PCOS) have increased risk for pregnancy complications, possibly related to pre-existing obesity and excessive gestational weight gain (GWG). Objectives: To assess the contributions of diagnosis and preconception weight on GWG and perinatal outcomes. Research Design and Methods: Prospective cohort study of singleton pregnancies in PCOS (n = 164) and ovulatory controls (n = 176) from infertility treatment. Main Outcome Measures: GWG, birthweight, pregnancy complications. Results: From preconception baseline, normal-weight women with PCOS gained 2.3 pounds more during the first trimester (95% CI, 0.3 to 4.3; P = 0.02), and by the end of the second trimester, 4.2 pounds more than controls (95% CI, 0.7 to 7.7; P = 0.02). Women who were overweight with PCOS gained significantly more weight than did controls by the end of the second trimester (5.2 pounds; 95% CI, 0.2 to 10.2; P = 0.04), whereas women with obesity and PCOS and control women had similar weight gain throughout pregnancy. Within normal-weight, overweight, and obese groups, prevalence of pre-eclampsia and gestational diabetes did not differ between the PCOS and control groups, nor was there a difference in birthweight. Preconception body mass index (BMI) was significantly associated with GWG; for every 1-kg/m 2 increase in preconception BMI, GWG decreased by 0.62 pounds (95% CI, 20.85 to 20.40; P, 0.001). Conclusions: Women with PCOS who are of normal weight or are overweight before conception experience more GWG than do ovulatory controls. Within normal-weight, overweight, and obese groups, rates of perinatal complications do not significantly differ between women with PCOS and controls. Preconception BMI is the strongest predictor of GWG.

Original languageEnglish (US)
Pages (from-to)4315-4323
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Issue number11
StatePublished - 2018
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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