Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk

Gregory A. Hawkins; Josyf C. Mychaleckyj; Siqun L. Zheng; Dennis A. Faith; Brian Kelly; S. D. Isaacs; Kathleen E. Wiley; Bao Li Chang; Charles M. Ewing; Piroska Bujnovszky; Eugene R. Bleecker; P. C. Walsh; Deborah A. Meyers; William B. Isaacs; Jianfeng Xu

doi:10.1016/S0165-4608(02)00549-6

Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk

Gregory A. Hawkins, Josyf C. Mychaleckyj, Siqun L. Zheng, Dennis A. Faith, Brian Kelly, S. D. Isaacs, Kathleen E. Wiley, Bao Li Chang, Charles M. Ewing, Piroska Bujnovszky, Eugene R. Bleecker, P. C. Walsh, Deborah A. Meyers, William B. Isaacs, Jianfeng Xu

School of Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The 8p22∼p23 region has been identified as a potential site for genes associated with prostate cancer. The gene LZTS1 has been mapped to the 8p22∼p23 region and identified as a potential tumor suppressor based on loss of heterozygosity studies using primary esophageal tumors. Sequence analysis of mRNA from various tumors has revealed multiple mutations and aberrant mRNA transcripts. The most recent report associates LZTS1 function with stabilization of p34^cdc2 during the late S-G₂/M stage of mitosis, affecting normal cell growth. In this study, a detailed DNA sequence analysis of LZTS1 was performed in a screening panel consisting of sporadic and hereditary prostate cancer (HPC) cases and unaffected controls. Twenty-four SNP, 15 of which were novel, were identified in germline DNA. Four coding SNP were identified. Eleven informative SNP were genotyped in 159 HPC probands, 245 sporadic prostate cancer cases, and 222 unaffected controls. Four of these SNP were statistically significant for association with prostate cancer (P ≤ 0.04). These results add evidence supporting a role of LZTS1 in prostate cancer risk.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Cancer Genetics and Cytogenetics
Volume	137
Issue number	1
DOIs	https://doi.org/10.1016/S0165-4608(02)00549-6
State	Published - Aug 2002

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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Hawkins, G. A., Mychaleckyj, J. C., Zheng, S. L., Faith, D. A., Kelly, B., Isaacs, S. D., Wiley, K. E., Chang, B. L., Ewing, C. M., Bujnovszky, P., Bleecker, E. R., Walsh, P. C., Meyers, D. A., Isaacs, W. B., & Xu, J. (2002). Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk. Cancer Genetics and Cytogenetics, 137(1), 1-7. https://doi.org/10.1016/S0165-4608(02)00549-6

Hawkins, GA, Mychaleckyj, JC, Zheng, SL, Faith, DA, Kelly, B, Isaacs, SD, Wiley, KE, Chang, BL, Ewing, CM, Bujnovszky, P, Bleecker, ER, Walsh, PC, Meyers, DA, Isaacs, WB & Xu, J 2002, 'Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk', Cancer Genetics and Cytogenetics, vol. 137, no. 1, pp. 1-7. https://doi.org/10.1016/S0165-4608(02)00549-6

@article{52f6e658c58e4e0caf22e59531314681,

title = "Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk",

abstract = "The 8p22∼p23 region has been identified as a potential site for genes associated with prostate cancer. The gene LZTS1 has been mapped to the 8p22∼p23 region and identified as a potential tumor suppressor based on loss of heterozygosity studies using primary esophageal tumors. Sequence analysis of mRNA from various tumors has revealed multiple mutations and aberrant mRNA transcripts. The most recent report associates LZTS1 function with stabilization of p34cdc2 during the late S-G2/M stage of mitosis, affecting normal cell growth. In this study, a detailed DNA sequence analysis of LZTS1 was performed in a screening panel consisting of sporadic and hereditary prostate cancer (HPC) cases and unaffected controls. Twenty-four SNP, 15 of which were novel, were identified in germline DNA. Four coding SNP were identified. Eleven informative SNP were genotyped in 159 HPC probands, 245 sporadic prostate cancer cases, and 222 unaffected controls. Four of these SNP were statistically significant for association with prostate cancer (P ≤ 0.04). These results add evidence supporting a role of LZTS1 in prostate cancer risk.",

author = "Hawkins, {Gregory A.} and Mychaleckyj, {Josyf C.} and Zheng, {Siqun L.} and Faith, {Dennis A.} and Brian Kelly and Isaacs, {S. D.} and Wiley, {Kathleen E.} and Chang, {Bao Li} and Ewing, {Charles M.} and Piroska Bujnovszky and Bleecker, {Eugene R.} and Walsh, {P. C.} and Meyers, {Deborah A.} and Isaacs, {William B.} and Jianfeng Xu",

note = "Funding Information: We wish to thank Debbie Kiger, Scott Binford, and Catherine Brewer for their technical expertise as well as all of the patients that participated in this study. We would also like to thank Aubrey Turner for critical reading of the manuscript. This work was partially supported by PHS SPORE grants to W.B.I. and J.X.",

year = "2002",

month = aug,

doi = "10.1016/S0165-4608(02)00549-6",

language = "English (US)",

volume = "137",

pages = "1--7",

journal = "Cancer Genetics and Cytogenetics",

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T1 - Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk

AU - Hawkins, Gregory A.

AU - Mychaleckyj, Josyf C.

AU - Zheng, Siqun L.

AU - Faith, Dennis A.

AU - Kelly, Brian

AU - Isaacs, S. D.

AU - Wiley, Kathleen E.

AU - Chang, Bao Li

AU - Ewing, Charles M.

AU - Bujnovszky, Piroska

AU - Bleecker, Eugene R.

AU - Walsh, P. C.

AU - Meyers, Deborah A.

AU - Isaacs, William B.

AU - Xu, Jianfeng

N1 - Funding Information: We wish to thank Debbie Kiger, Scott Binford, and Catherine Brewer for their technical expertise as well as all of the patients that participated in this study. We would also like to thank Aubrey Turner for critical reading of the manuscript. This work was partially supported by PHS SPORE grants to W.B.I. and J.X.

PY - 2002/8

Y1 - 2002/8

N2 - The 8p22∼p23 region has been identified as a potential site for genes associated with prostate cancer. The gene LZTS1 has been mapped to the 8p22∼p23 region and identified as a potential tumor suppressor based on loss of heterozygosity studies using primary esophageal tumors. Sequence analysis of mRNA from various tumors has revealed multiple mutations and aberrant mRNA transcripts. The most recent report associates LZTS1 function with stabilization of p34cdc2 during the late S-G2/M stage of mitosis, affecting normal cell growth. In this study, a detailed DNA sequence analysis of LZTS1 was performed in a screening panel consisting of sporadic and hereditary prostate cancer (HPC) cases and unaffected controls. Twenty-four SNP, 15 of which were novel, were identified in germline DNA. Four coding SNP were identified. Eleven informative SNP were genotyped in 159 HPC probands, 245 sporadic prostate cancer cases, and 222 unaffected controls. Four of these SNP were statistically significant for association with prostate cancer (P ≤ 0.04). These results add evidence supporting a role of LZTS1 in prostate cancer risk.

AB - The 8p22∼p23 region has been identified as a potential site for genes associated with prostate cancer. The gene LZTS1 has been mapped to the 8p22∼p23 region and identified as a potential tumor suppressor based on loss of heterozygosity studies using primary esophageal tumors. Sequence analysis of mRNA from various tumors has revealed multiple mutations and aberrant mRNA transcripts. The most recent report associates LZTS1 function with stabilization of p34cdc2 during the late S-G2/M stage of mitosis, affecting normal cell growth. In this study, a detailed DNA sequence analysis of LZTS1 was performed in a screening panel consisting of sporadic and hereditary prostate cancer (HPC) cases and unaffected controls. Twenty-four SNP, 15 of which were novel, were identified in germline DNA. Four coding SNP were identified. Eleven informative SNP were genotyped in 159 HPC probands, 245 sporadic prostate cancer cases, and 222 unaffected controls. Four of these SNP were statistically significant for association with prostate cancer (P ≤ 0.04). These results add evidence supporting a role of LZTS1 in prostate cancer risk.

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Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk

Abstract

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