Germ cell tumors: An update of recent data and review of active protocols in stage I and metastatic disease

Noah M. Hahn; Christopher J. Sweeney

doi:10.1016/j.urolonc.2005.05.008

Germ cell tumors: An update of recent data and review of active protocols in stage I and metastatic disease

Noah M. Hahn, Christopher J. Sweeney

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Germ cell tumors are highly curable malignancies even when metastatic. Investigations currently focus on curtailing toxicity in low-risk patients and improving cure rates in poor-risk individuals. Reduced dose radiation schedules and short-course chemotherapy regimens have been evaluated in stage I disease. In metastatic disease, several new nonplatinum agents offer promise for patients with poor risk or relapsed disease. In addition, high-dose chemotherapy regimens with autologous stem cell transplant provide potential for further improvements in survival. This review will highlight recent developments and currently active clinical trials pertinent to the treatment of patients with germ cell tumors.

Original language	English (US)
Pages (from-to)	293-302
Number of pages	10
Journal	Urologic Oncology: Seminars and Original Investigations
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.urolonc.2005.05.008
State	Published - Jul 2005
Externally published	Yes

Keywords

Clinical trials
Evidence
Germ cell tumor
Metastases
Nonseminoma
Seminoma
Stage I
Update

ASJC Scopus subject areas

Oncology
Urology

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10.1016/j.urolonc.2005.05.008

Cite this

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title = "Germ cell tumors: An update of recent data and review of active protocols in stage I and metastatic disease",

abstract = "Germ cell tumors are highly curable malignancies even when metastatic. Investigations currently focus on curtailing toxicity in low-risk patients and improving cure rates in poor-risk individuals. Reduced dose radiation schedules and short-course chemotherapy regimens have been evaluated in stage I disease. In metastatic disease, several new nonplatinum agents offer promise for patients with poor risk or relapsed disease. In addition, high-dose chemotherapy regimens with autologous stem cell transplant provide potential for further improvements in survival. This review will highlight recent developments and currently active clinical trials pertinent to the treatment of patients with germ cell tumors.",

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AU - Sweeney, Christopher J.

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AB - Germ cell tumors are highly curable malignancies even when metastatic. Investigations currently focus on curtailing toxicity in low-risk patients and improving cure rates in poor-risk individuals. Reduced dose radiation schedules and short-course chemotherapy regimens have been evaluated in stage I disease. In metastatic disease, several new nonplatinum agents offer promise for patients with poor risk or relapsed disease. In addition, high-dose chemotherapy regimens with autologous stem cell transplant provide potential for further improvements in survival. This review will highlight recent developments and currently active clinical trials pertinent to the treatment of patients with germ cell tumors.

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KW - Evidence

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KW - Metastases

KW - Nonseminoma

KW - Seminoma

KW - Stage I

KW - Update

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Germ cell tumors: An update of recent data and review of active protocols in stage I and metastatic disease

Abstract

Keywords

ASJC Scopus subject areas

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