Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Jeffrey C. Barrett; Sarah Hansoul; Dan L. Nicolae; Judy H. Cho; Richard H. Duerr; John D. Rioux; Steven R. Brant; Mark S. Silverberg; Kent D. Taylor; M. Michael Barmada; Alain Bitton; Themistocles Dassopoulos; Lisa Wu Datta; Todd Green; Anne M. Griffiths; Emily O. Kistner; Michael T. Murtha; Miguel D. Regueiro; Jerome I. Rotter; L. Philip Schumm; A. Hillary Steinhart; Stephan R. Targan; Ramnik J. Xavier; Cécile Libioulle; Cynthia Sandor; Mark Lathrop; Jacques Belaiche; Olivier Dewit; Ivo Gut; Simon Heath; Debby Laukens; Myriam Mni; Paul Rutgeerts; André Van Gossum; Diana Zelenika; Denis Franchimont; Jean Pierre Hugot; Martine De Vos; Severine Vermeire; Edouard Louis; Lon R. Cardon; Carl A. Anderson; Hazel Drummond; Elaine Nimmo; Tariq Ahmad; Natalie J. Prescott; Clive M. Onnie; Sheila A. Fisher; Jonathan Marchini; Jilur Ghori; Suzannah Bumpstead; Rhian Gwilliam; Mark Tremelling; Panos Deloukas; John Mansfield; Derek Jewell; Jack Satsangi; Christopher G. Mathew; Miles Parkes; Michel Georges; Mark J. Daly

doi:10.1038/ng.175

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Jeffrey C. Barrett, Sarah Hansoul, Dan L. Nicolae, Judy H. Cho, Richard H. Duerr, John D. Rioux, Steven R. Brant, Mark S. Silverberg, Kent D. Taylor, M. Michael Barmada, Alain Bitton, Themistocles Dassopoulos, Lisa Wu Datta, Todd Green, Anne M. Griffiths, Emily O. Kistner, Michael T. Murtha, Miguel D. Regueiro, Jerome I. Rotter, L. Philip SchummA. Hillary Steinhart, Stephan R. Targan, Ramnik J. Xavier, Cécile Libioulle, Cynthia Sandor, Mark Lathrop, Jacques Belaiche, Olivier Dewit, Ivo Gut, Simon Heath, Debby Laukens, Myriam Mni, Paul Rutgeerts, André Van Gossum, Diana Zelenika, Denis Franchimont, Jean Pierre Hugot, Martine De Vos, Severine Vermeire, Edouard Louis, Lon R. Cardon, Carl A. Anderson, Hazel Drummond, Elaine Nimmo, Tariq Ahmad, Natalie J. Prescott, Clive M. Onnie, Sheila A. Fisher, Jonathan Marchini, Jilur Ghori, Suzannah Bumpstead, Rhian Gwilliam, Mark Tremelling, Panos Deloukas, John Mansfield, Derek Jewell, Jack Satsangi, Christopher G. Mathew, Miles Parkes, Michel Georges, Mark J. Daly

Research output: Contribution to journal › Article › peer-review

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Abstract

Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.

Original language	English (US)
Pages (from-to)	955-962
Number of pages	8
Journal	Nature genetics
Volume	40
Issue number	8
DOIs	https://doi.org/10.1038/ng.175
State	Published - Aug 2008
Externally published	Yes

ASJC Scopus subject areas

Genetics

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Barrett, J. C., Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., Silverberg, M. S., Taylor, K. D., Barmada, M. M., Bitton, A., Dassopoulos, T., Datta, L. W., Green, T., Griffiths, A. M., Kistner, E. O., Murtha, M. T., Regueiro, M. D., Rotter, J. I., ... Daly, M. J. (2008). Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nature genetics, 40(8), 955-962. https://doi.org/10.1038/ng.175

Barrett, JC, Hansoul, S, Nicolae, DL, Cho, JH, Duerr, RH, Rioux, JD, Brant, SR, Silverberg, MS, Taylor, KD, Barmada, MM, Bitton, A, Dassopoulos, T, Datta, LW, Green, T, Griffiths, AM, Kistner, EO, Murtha, MT, Regueiro, MD, Rotter, JI, Schumm, LP, Steinhart, AH, Targan, SR, Xavier, RJ, Libioulle, C, Sandor, C, Lathrop, M, Belaiche, J, Dewit, O, Gut, I, Heath, S, Laukens, D, Mni, M, Rutgeerts, P, Van Gossum, A, Zelenika, D, Franchimont, D, Hugot, JP, De Vos, M, Vermeire, S, Louis, E, Cardon, LR, Anderson, CA, Drummond, H, Nimmo, E, Ahmad, T, Prescott, NJ, Onnie, CM, Fisher, SA, Marchini, J, Ghori, J, Bumpstead, S, Gwilliam, R, Tremelling, M, Deloukas, P, Mansfield, J, Jewell, D, Satsangi, J, Mathew, CG, Parkes, M, Georges, M & Daly, MJ 2008, 'Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease', Nature genetics, vol. 40, no. 8, pp. 955-962. https://doi.org/10.1038/ng.175

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title = "Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease",

abstract = "Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.",

author = "Barrett, {Jeffrey C.} and Sarah Hansoul and Nicolae, {Dan L.} and Cho, {Judy H.} and Duerr, {Richard H.} and Rioux, {John D.} and Brant, {Steven R.} and Silverberg, {Mark S.} and Taylor, {Kent D.} and Barmada, {M. Michael} and Alain Bitton and Themistocles Dassopoulos and Datta, {Lisa Wu} and Todd Green and Griffiths, {Anne M.} and Kistner, {Emily O.} and Murtha, {Michael T.} and Regueiro, {Miguel D.} and Rotter, {Jerome I.} and Schumm, {L. Philip} and Steinhart, {A. Hillary} and Targan, {Stephan R.} and Xavier, {Ramnik J.} and C{\'e}cile Libioulle and Cynthia Sandor and Mark Lathrop and Jacques Belaiche and Olivier Dewit and Ivo Gut and Simon Heath and Debby Laukens and Myriam Mni and Paul Rutgeerts and {Van Gossum}, Andr{\'e} and Diana Zelenika and Denis Franchimont and Hugot, {Jean Pierre} and {De Vos}, Martine and Severine Vermeire and Edouard Louis and Cardon, {Lon R.} and Anderson, {Carl A.} and Hazel Drummond and Elaine Nimmo and Tariq Ahmad and Prescott, {Natalie J.} and Onnie, {Clive M.} and Fisher, {Sheila A.} and Jonathan Marchini and Jilur Ghori and Suzannah Bumpstead and Rhian Gwilliam and Mark Tremelling and Panos Deloukas and John Mansfield and Derek Jewell and Jack Satsangi and Mathew, {Christopher G.} and Miles Parkes and Michel Georges and Daly, {Mark J.}",

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AU - Nicolae, Dan L.

AU - Cho, Judy H.

AU - Duerr, Richard H.

AU - Rioux, John D.

AU - Brant, Steven R.

AU - Silverberg, Mark S.

AU - Taylor, Kent D.

AU - Barmada, M. Michael

AU - Bitton, Alain

AU - Dassopoulos, Themistocles

AU - Datta, Lisa Wu

AU - Green, Todd

AU - Griffiths, Anne M.

AU - Kistner, Emily O.

AU - Murtha, Michael T.

AU - Regueiro, Miguel D.

AU - Rotter, Jerome I.

AU - Schumm, L. Philip

AU - Steinhart, A. Hillary

AU - Targan, Stephan R.

AU - Xavier, Ramnik J.

AU - Libioulle, Cécile

AU - Sandor, Cynthia

AU - Lathrop, Mark

AU - Belaiche, Jacques

AU - Dewit, Olivier

AU - Gut, Ivo

AU - Heath, Simon

AU - Laukens, Debby

AU - Mni, Myriam

AU - Rutgeerts, Paul

AU - Van Gossum, André

AU - Zelenika, Diana

AU - Franchimont, Denis

AU - Hugot, Jean Pierre

AU - De Vos, Martine

AU - Vermeire, Severine

AU - Louis, Edouard

AU - Cardon, Lon R.

AU - Anderson, Carl A.

AU - Drummond, Hazel

AU - Nimmo, Elaine

AU - Ahmad, Tariq

AU - Prescott, Natalie J.

AU - Onnie, Clive M.

AU - Fisher, Sheila A.

AU - Marchini, Jonathan

AU - Ghori, Jilur

AU - Bumpstead, Suzannah

AU - Gwilliam, Rhian

AU - Tremelling, Mark

AU - Deloukas, Panos

AU - Mansfield, John

AU - Jewell, Derek

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AU - Georges, Michel

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AB - Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.

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JF - Nature genetics

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

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