Genome screen for asthma and bronchial hyperresponsiveness: Interactions with passive smoke exposure

Deborah A. Meyers; Dirkje S. Postma; O. Colin Stine; Gerard H. Koppelman; Elizabeth J. Ampleford; Hajo Jongepier; Timothy D. Howard; Eugene R. Bleecker

doi:10.1016/j.jaci.2005.01.070

Genome screen for asthma and bronchial hyperresponsiveness: Interactions with passive smoke exposure

Deborah A. Meyers, Dirkje S. Postma, O. Colin Stine, Gerard H. Koppelman, Elizabeth J. Ampleford, Hajo Jongepier, Timothy D. Howard, Eugene R. Bleecker

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

Background: Asthma is a common respiratory disease caused by the interaction of genetic susceptibility and exposure to various environmental factors. Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma. Objective: We sought to perform a genome-wide linkage screen for asthma and bronchial hyperresponsiveness (BHR) and to determine the influence of passive tobacco smoke exposure during childhood on the results of genetic linkage studies to investigate gene-environment interactions. Methods: A genome-wide linkage screen for asthma and BHR was performed in 200 families ascertained through a parent with asthma. Analyses were performed separately for the entire sample and for the smoking-exposed and nonexposed families. For asthma and BHR, the strongest evidence for linkage was observed for chromosomes 3p and 5q. The families in which the children were exposed to passive smoking accounted for the evidence for linkage of BHR to 5q (P

Original language	English (US)
Pages (from-to)	1169-1175
Number of pages	7
Journal	The Journal of Allergy and Clinical Immunology
Volume	115
Issue number	6
DOIs	https://doi.org/10.1016/j.jaci.2005.01.070
State	Published - Jun 2005
Externally published	Yes

Keywords

Asthma
Bronchial hyperresponsiveness
Genome-wide screen
Linkage
Lung function
Smoking

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.jaci.2005.01.070

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title = "Genome screen for asthma and bronchial hyperresponsiveness: Interactions with passive smoke exposure",

abstract = "Background: Asthma is a common respiratory disease caused by the interaction of genetic susceptibility and exposure to various environmental factors. Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma. Objective: We sought to perform a genome-wide linkage screen for asthma and bronchial hyperresponsiveness (BHR) and to determine the influence of passive tobacco smoke exposure during childhood on the results of genetic linkage studies to investigate gene-environment interactions. Methods: A genome-wide linkage screen for asthma and BHR was performed in 200 families ascertained through a parent with asthma. Analyses were performed separately for the entire sample and for the smoking-exposed and nonexposed families. For asthma and BHR, the strongest evidence for linkage was observed for chromosomes 3p and 5q. The families in which the children were exposed to passive smoking accounted for the evidence for linkage of BHR to 5q (P ",

keywords = "Asthma, Bronchial hyperresponsiveness, Genome-wide screen, Linkage, Lung function, Smoking",

author = "Meyers, {Deborah A.} and Postma, {Dirkje S.} and Stine, {O. Colin} and Koppelman, {Gerard H.} and Ampleford, {Elizabeth J.} and Hajo Jongepier and Howard, {Timothy D.} and Bleecker, {Eugene R.}",

year = "2005",

month = jun,

doi = "10.1016/j.jaci.2005.01.070",

language = "English (US)",

volume = "115",

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journal = "The Journal of Allergy and Clinical Immunology",

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T2 - Interactions with passive smoke exposure

AU - Meyers, Deborah A.

AU - Postma, Dirkje S.

AU - Stine, O. Colin

AU - Koppelman, Gerard H.

AU - Ampleford, Elizabeth J.

AU - Jongepier, Hajo

AU - Howard, Timothy D.

AU - Bleecker, Eugene R.

PY - 2005/6

Y1 - 2005/6

N2 - Background: Asthma is a common respiratory disease caused by the interaction of genetic susceptibility and exposure to various environmental factors. Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma. Objective: We sought to perform a genome-wide linkage screen for asthma and bronchial hyperresponsiveness (BHR) and to determine the influence of passive tobacco smoke exposure during childhood on the results of genetic linkage studies to investigate gene-environment interactions. Methods: A genome-wide linkage screen for asthma and BHR was performed in 200 families ascertained through a parent with asthma. Analyses were performed separately for the entire sample and for the smoking-exposed and nonexposed families. For asthma and BHR, the strongest evidence for linkage was observed for chromosomes 3p and 5q. The families in which the children were exposed to passive smoking accounted for the evidence for linkage of BHR to 5q (P

AB - Background: Asthma is a common respiratory disease caused by the interaction of genetic susceptibility and exposure to various environmental factors. Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma. Objective: We sought to perform a genome-wide linkage screen for asthma and bronchial hyperresponsiveness (BHR) and to determine the influence of passive tobacco smoke exposure during childhood on the results of genetic linkage studies to investigate gene-environment interactions. Methods: A genome-wide linkage screen for asthma and BHR was performed in 200 families ascertained through a parent with asthma. Analyses were performed separately for the entire sample and for the smoking-exposed and nonexposed families. For asthma and BHR, the strongest evidence for linkage was observed for chromosomes 3p and 5q. The families in which the children were exposed to passive smoking accounted for the evidence for linkage of BHR to 5q (P

KW - Asthma

KW - Bronchial hyperresponsiveness

KW - Genome-wide screen

KW - Linkage

KW - Lung function

KW - Smoking

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Genome screen for asthma and bronchial hyperresponsiveness: Interactions with passive smoke exposure

Abstract

Keywords

ASJC Scopus subject areas

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