Genome screen for asthma and bronchial hyperresponsiveness: Interactions with passive smoke exposure

Deborah A. Meyers, Dirkje S. Postma, O. Colin Stine, Gerard H. Koppelman, Elizabeth J. Ampleford, Hajo Jongepier, Timothy D. Howard, Eugene R. Bleecker

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


Background: Asthma is a common respiratory disease caused by the interaction of genetic susceptibility and exposure to various environmental factors. Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma. Objective: We sought to perform a genome-wide linkage screen for asthma and bronchial hyperresponsiveness (BHR) and to determine the influence of passive tobacco smoke exposure during childhood on the results of genetic linkage studies to investigate gene-environment interactions. Methods: A genome-wide linkage screen for asthma and BHR was performed in 200 families ascertained through a parent with asthma. Analyses were performed separately for the entire sample and for the smoking-exposed and nonexposed families. For asthma and BHR, the strongest evidence for linkage was observed for chromosomes 3p and 5q. The families in which the children were exposed to passive smoking accounted for the evidence for linkage of BHR to 5q (P

Original languageEnglish (US)
Pages (from-to)1169-1175
Number of pages7
JournalThe Journal of Allergy and Clinical Immunology
Issue number6
StatePublished - Jun 2005
Externally publishedYes


  • Asthma
  • Bronchial hyperresponsiveness
  • Genome-wide screen
  • Linkage
  • Lung function
  • Smoking

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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