Genital tract sequestration of SIV following acute infection

James B. Whitney; Peter T. Hraber; Corinne Luedemann; Elena E. Giorgi; Marcus G. Daniels; Tanmoy Bhattacharya; Srinivas S. Rao; John R. Mascola; Gary J. Nabel; Bette T. Korber; Norman L. Letvin

doi:10.1371/journal.ppat.1001293

Genital tract sequestration of SIV following acute infection

James B. Whitney, Peter T. Hraber, Corinne Luedemann, Elena E. Giorgi, Marcus G. Daniels, Tanmoy Bhattacharya, Srinivas S. Rao, John R. Mascola, Gary J. Nabel, Bette T. Korber, Norman L. Letvin

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.

Original language	English (US)
Article number	e1001293
Journal	PLoS pathogens
Volume	7
Issue number	2
DOIs	https://doi.org/10.1371/journal.ppat.1001293
State	Published - Feb 2011
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Molecular Biology
Genetics
Virology

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title = "Genital tract sequestration of SIV following acute infection",

abstract = "We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus {"}spillover{"} into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.",

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AU - Hraber, Peter T.

AU - Luedemann, Corinne

AU - Giorgi, Elena E.

AU - Daniels, Marcus G.

AU - Bhattacharya, Tanmoy

AU - Rao, Srinivas S.

AU - Mascola, John R.

AU - Nabel, Gary J.

AU - Korber, Bette T.

AU - Letvin, Norman L.

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Genital tract sequestration of SIV following acute infection

Abstract

ASJC Scopus subject areas

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