Genetics of Parkinson's disease and parkinsonism

John Hardy, Huaiban Cai, Mark R. Cookson, Katrina Gwinn-Hardy, Andrew Singleton

Research output: Contribution to journalReview articlepeer-review

265 Scopus citations


Until 10 years ago, conventional wisdom held that Parkinson's disease was not a genetic disorder. Since that time, there have been a plethora of genetic findings, culminating in the cloning of sevetal genes that derive from the loci given the nomenclature PARK1-PARK12 (OMIM 168600). Recently, these research findings have begun to impact clinical practice, and this impact is likely to increase. The primary purpose of this article is to outline these genetic advances, discuss their importance for current practice in clinical and related settings, and outline briefly how they are influencing research into the causes of and possible future treatments for this prevalent disorder.

Original languageEnglish (US)
Pages (from-to)389-398
Number of pages10
JournalAnnals of neurology
Issue number4
StatePublished - Oct 2006
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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