Genetics of Human Anxiety and Its Disorders

A. R. Hariri; D. R. Weinberger

doi:10.1016/B978-008045046-9.00845-7

Genetics of Human Anxiety and Its Disorders

A. R. Hariri, D. R. Weinberger

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Normal variation in human emotionality, in temperament and risk for affective disorders, is explained to a large degree by genetic variation. The sequencing of the human genome has made it possible to test the role of specific genes on measures of human emotionality, on risk for affective disorders, and on the brain systems that appear to mediate emotion-related phenotypes. A novel approach, called imaging genetics, has shown that several genes that impact on brain serotonergic signaling affect the development and function of circuits of the limbic system involved in emotional experience and behavior.

Original language	English (US)
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd
Pages	669-677
Number of pages	9
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.00845-7
State	Published - Jan 1 2009
Externally published	Yes

Keywords

5HTTLPR
Anxiety
BDNF
Depression
FMRI
Genetics
MAOA
Neuroimaging
TPH
Temperament

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/B978-008045046-9.00845-7

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AB - Normal variation in human emotionality, in temperament and risk for affective disorders, is explained to a large degree by genetic variation. The sequencing of the human genome has made it possible to test the role of specific genes on measures of human emotionality, on risk for affective disorders, and on the brain systems that appear to mediate emotion-related phenotypes. A novel approach, called imaging genetics, has shown that several genes that impact on brain serotonergic signaling affect the development and function of circuits of the limbic system involved in emotional experience and behavior.

KW - 5HTTLPR

KW - Anxiety

KW - BDNF

KW - Depression

KW - FMRI

KW - Genetics

KW - MAOA

KW - Neuroimaging

KW - TPH

KW - Temperament

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EP - 677

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -

Genetics of Human Anxiety and Its Disorders

Abstract

Keywords

ASJC Scopus subject areas

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