Genetic variation of capsule/LPS biogenesis in two serogroup O31 Vibrio cholerae isolates

Yuansha Chen, O. Colin Stine, J. Glenn Morris, Judith A. Johnson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Both NRT36S and A5 are NAG-ST-producing, serogroup O31 Vibrio cholerae. NRT36S is encapsulated and causes diarrhea when administered to volunteers; A5 is unencapsulated and does not colonize or cause illness in humans. The capsule/LPS (CPS/LPS) biogenesis regions in these two isolates were similar except that a 6.5-kb fragment in A5 has replaced a 10-kb fragment in NRT36S in the middle of the CPS/LPS gene cluster. Although the genes of the replaced region were homologous to genes from other CPS/LPS, they had little similarity to NRT36S and were not homologous to genes from other Vibrios. Data of this study highlight the apparent mobility within the CPS/LPS region that would provide a basis for the large number of observed V. cholerae serogroups and the emergence of novel epidemic strains.

Original languageEnglish (US)
Pages (from-to)133-139
Number of pages7
JournalFEMS Microbiology Letters
Issue number2
StatePublished - Aug 2007
Externally publishedYes


  • Gene transfer
  • Serogroup
  • Vibrio cholerae

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology


Dive into the research topics of 'Genetic variation of capsule/LPS biogenesis in two serogroup O31 Vibrio cholerae isolates'. Together they form a unique fingerprint.

Cite this