Genetic variability of clinical chemical values

R. Havlik, R. Garrison, R. Fabsitz, M. Feinleib

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A study of cardiovascular risk factors in middle aged twin men provided an opportunity to test for genetic variability in the SMA 12/60 (Technicon) battery of clinical chemistry tests. Classical twin methodology was used to analyze the variation of monozygotic and dizygotic twins. In addition, frequency of co twin contact was used to control for effects of differences in shared environment. Genetic variability played a definite role in controlling four of the 11 reported tests: one hour serum glucose, serum urea nitrogen, uric acid, and bilirubin. No genetic variation was found for lactate dehydrogenase, phosphorus, and alkaline phosphatase. Significantly higher means for calcium, total protein, albumin, and aspartate aminotransferase in monozygotic twins precluded any statement about heredity and environment for these tests.

Original languageEnglish (US)
Pages (from-to)659-662
Number of pages4
JournalClinical Chemistry
Issue number4
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry


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