Genetic Spectrum and Distinct Evolution Patterns of SARS-CoV-2

Sheng Liu, Jikui Shen, Shuyi Fang, Kailing Li, Juli Liu, Lei Yang, Chang Deng Hu, Jun Wan

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Four signature groups of frequently occurred single-nucleotide variants (SNVs) were identified in over twenty-eight thousand high-quality and high-coverage SARS-CoV-2 complete genome sequences, representing different viral strains. Some SNVs predominated but were mutually exclusively presented in patients from different countries and areas. These major SNV signatures exhibited distinguishable evolution patterns over time. A few hundred patients were detected with multiple viral strain-representing mutations simultaneously, which may stand for possible co-infection or potential homogenous recombination of SARS-CoV-2 in environment or within the viral host. Interestingly nucleotide substitutions among SARS-CoV-2 genomes tended to switch between bat RaTG13 coronavirus sequence and Wuhan-Hu-1 genome, indicating the higher genetic instability or tolerance of mutations on those sites or suggesting that major viral strains might exist between Wuhan-Hu-1 and RaTG13 coronavirus.

Original languageEnglish (US)
Article number593548
JournalFrontiers in Microbiology
StatePublished - Sep 25 2020


  • COVID-19
  • SARS-CoV-2 genome
  • clustering
  • co-infection
  • evolution
  • genetic variants

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


Dive into the research topics of 'Genetic Spectrum and Distinct Evolution Patterns of SARS-CoV-2'. Together they form a unique fingerprint.

Cite this