Genetic markers of IgG influence the outcome of infection with hepatitis C virus

Janardan P. Pandey; Aryan M. Namboodiri; Yuqun Luo; Yuping Wu; Robert C. Elston; David L. Thomas; Hugo R. Rosen; James J. Goedert

doi:10.1086/592282

Genetic markers of IgG influence the outcome of infection with hepatitis C virus

Janardan P. Pandey, Aryan M. Namboodiri, Yuqun Luo, Yuping Wu, Robert C. Elston, David L. Thomas, Hugo R. Rosen, James J. Goedert

School of Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We examined the role that immunoglobulin GM and KM allotypes - genetic markers of γ and κ chains, respectively - play in the outcome of hepatitis C virus (HCV) infection in white Americans. A total of 119 persons who had cleared HCV and 111 with persistent HCV infection were genotyped for the presence of several GM and KM determinants. Persistent HCV infection was more than three times as likely (odds ratio, 3.50; P = .01) in subjects who were carriers of the GM3 allele than in those who were noncarriers. These results show that particular GM alleles may be important determinants of the outcome of HCV infection.

Original language	English (US)
Pages (from-to)	1334-1336
Number of pages	3
Journal	Journal of Infectious Diseases
Volume	198
Issue number	9
DOIs	https://doi.org/10.1086/592282
State	Published - Nov 1 2008

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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title = "Genetic markers of IgG influence the outcome of infection with hepatitis C virus",

abstract = "We examined the role that immunoglobulin GM and KM allotypes - genetic markers of γ and κ chains, respectively - play in the outcome of hepatitis C virus (HCV) infection in white Americans. A total of 119 persons who had cleared HCV and 111 with persistent HCV infection were genotyped for the presence of several GM and KM determinants. Persistent HCV infection was more than three times as likely (odds ratio, 3.50; P = .01) in subjects who were carriers of the GM3 allele than in those who were noncarriers. These results show that particular GM alleles may be important determinants of the outcome of HCV infection.",

author = "Pandey, {Janardan P.} and Namboodiri, {Aryan M.} and Yuqun Luo and Yuping Wu and Elston, {Robert C.} and Thomas, {David L.} and Rosen, {Hugo R.} and Goedert, {James J.}",

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AU - Pandey, Janardan P.

AU - Namboodiri, Aryan M.

AU - Luo, Yuqun

AU - Wu, Yuping

AU - Elston, Robert C.

AU - Thomas, David L.

AU - Rosen, Hugo R.

AU - Goedert, James J.

PY - 2008/11/1

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N2 - We examined the role that immunoglobulin GM and KM allotypes - genetic markers of γ and κ chains, respectively - play in the outcome of hepatitis C virus (HCV) infection in white Americans. A total of 119 persons who had cleared HCV and 111 with persistent HCV infection were genotyped for the presence of several GM and KM determinants. Persistent HCV infection was more than three times as likely (odds ratio, 3.50; P = .01) in subjects who were carriers of the GM3 allele than in those who were noncarriers. These results show that particular GM alleles may be important determinants of the outcome of HCV infection.

AB - We examined the role that immunoglobulin GM and KM allotypes - genetic markers of γ and κ chains, respectively - play in the outcome of hepatitis C virus (HCV) infection in white Americans. A total of 119 persons who had cleared HCV and 111 with persistent HCV infection were genotyped for the presence of several GM and KM determinants. Persistent HCV infection was more than three times as likely (odds ratio, 3.50; P = .01) in subjects who were carriers of the GM3 allele than in those who were noncarriers. These results show that particular GM alleles may be important determinants of the outcome of HCV infection.

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Genetic markers of IgG influence the outcome of infection with hepatitis C virus

Abstract

ASJC Scopus subject areas

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