Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21

R. H. Reeves; B. F. O'Hara; W. J. Pavan; J. D. Gearhart; O. Haller

doi:10.1128/jvi.62.11.4372-4375.1988

Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21

R. H. Reeves, B. F. O'Hara, W. J. Pavan, J. D. Gearhart, O. Haller

School of Medicine

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

A total of 318 progeny from four backcrosses involving different laboratory strains and subspecies of Mus musculus were analyzed to map the Mx gene to the region of mouse chromosome 16 (MMU 16) which is homologous to human chromosome 21 (HSA 21). This result suggests that Mx will be found in the region of HSA 21 which has been implicated in Down syndrome when inherited in three copies.

Original language	English (US)
Pages (from-to)	4372-4375
Number of pages	4
Journal	Journal of virology
Volume	62
Issue number	11
DOIs	https://doi.org/10.1128/jvi.62.11.4372-4375.1988
State	Published - 1988

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.62.11.4372-4375.1988

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abstract = "A total of 318 progeny from four backcrosses involving different laboratory strains and subspecies of Mus musculus were analyzed to map the Mx gene to the region of mouse chromosome 16 (MMU 16) which is homologous to human chromosome 21 (HSA 21). This result suggests that Mx will be found in the region of HSA 21 which has been implicated in Down syndrome when inherited in three copies.",

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AU - Reeves, R. H.

AU - O'Hara, B. F.

AU - Pavan, W. J.

AU - Gearhart, J. D.

AU - Haller, O.

PY - 1988

Y1 - 1988

N2 - A total of 318 progeny from four backcrosses involving different laboratory strains and subspecies of Mus musculus were analyzed to map the Mx gene to the region of mouse chromosome 16 (MMU 16) which is homologous to human chromosome 21 (HSA 21). This result suggests that Mx will be found in the region of HSA 21 which has been implicated in Down syndrome when inherited in three copies.

AB - A total of 318 progeny from four backcrosses involving different laboratory strains and subspecies of Mus musculus were analyzed to map the Mx gene to the region of mouse chromosome 16 (MMU 16) which is homologous to human chromosome 21 (HSA 21). This result suggests that Mx will be found in the region of HSA 21 which has been implicated in Down syndrome when inherited in three copies.

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Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21

Abstract

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