Genetic etiology of hereditary prostate cancer

Wendy J. Langeberg; William B. Isaacs; Janet L. Stanford

doi:10.2741/2374

Genetic etiology of hereditary prostate cancer

Wendy J. Langeberg, William B. Isaacs, Janet L. Stanford

School of Medicine

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Prostate cancer (PC) is a pervasive disease both in terms of incidence and mortality, yet little is known about its etiologic factors. Twin and segregation studies provide evidence for an inherited genetic component to the etiology of PC, yet over a dozen family-based genetic linkage analyses have not been able to consistently identify susceptibility loci. This chapter will review these studies, describe the challenges of this endeavor, and describe efforts to confront these challenges, such as using larger sets of families and more homogeneous subgroups.

Original language	English (US)
Pages (from-to)	4101-4110
Number of pages	10
Journal	Frontiers in Bioscience
Volume	12
Issue number	11
DOIs	https://doi.org/10.2741/2374
State	Published - May 1 2007

Keywords

Genetic linkage
Hereditary
Prostate cancer
Review
Susceptibility genes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.2741/2374

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AB - Prostate cancer (PC) is a pervasive disease both in terms of incidence and mortality, yet little is known about its etiologic factors. Twin and segregation studies provide evidence for an inherited genetic component to the etiology of PC, yet over a dozen family-based genetic linkage analyses have not been able to consistently identify susceptibility loci. This chapter will review these studies, describe the challenges of this endeavor, and describe efforts to confront these challenges, such as using larger sets of families and more homogeneous subgroups.

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KW - Susceptibility genes

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Genetic etiology of hereditary prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

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