TY - JOUR
T1 - Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival
AU - Nowakowski, Adam
AU - Walczak, Piotr
AU - Lukomska, Barbara
AU - Janowski, Miroslaw
N1 - Publisher Copyright:
© 2016 Adam Nowakowski et al.
PY - 2016
Y1 - 2016
N2 - Mesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities, either naturally or induced through cell engineering. However, efficient methods of delivery to diseased tissues and the long-term survival of grafted cells still need improvement. Here, we review genetic engineering approaches designed to enhance the migratory capacities of MSCs, as well as extend their survival after transplantation by the modulation of prosurvival approaches, including prevention of senescence and apoptosis. We highlight some of the latest examples that explore these pivotal points, which have great relevance in cell-based therapies.
AB - Mesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities, either naturally or induced through cell engineering. However, efficient methods of delivery to diseased tissues and the long-term survival of grafted cells still need improvement. Here, we review genetic engineering approaches designed to enhance the migratory capacities of MSCs, as well as extend their survival after transplantation by the modulation of prosurvival approaches, including prevention of senescence and apoptosis. We highlight some of the latest examples that explore these pivotal points, which have great relevance in cell-based therapies.
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U2 - 10.1155/2016/4956063
DO - 10.1155/2016/4956063
M3 - Review article
C2 - 27242906
AN - SCOPUS:84966415798
SN - 1687-9678
VL - 2016
JO - Stem Cells International
JF - Stem Cells International
M1 - 4956063
ER -