Genetic diversity of O-antigen biosynthesis regions in Vibrio cholerae

Antonina Aydanian, Li Tang, J. Glenn Morris, Judith A. Johnson, O. Colin Stine

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


O-antigen biosynthetic (wbf) regions for Vibrio cholerae serogroups O5, O8, and O108 were isolated and sequenced. Sequences were compared to those of other published V. cholerae O-antigen regions. These wbf regions showed a high degree of heterogeneity both in gene content and in gene order. Genes identified frequently showed greater similarities to polysaccharide biosynthesis genes from species other than V. cholerae. Our results demonstrate the plasticity of O-antigen genes in V. cholerae, the diversity of the genetic pool from which they are drawn, and the likelihood that new pandemic serogroups will emerge.

Original languageEnglish (US)
Pages (from-to)2247-2253
Number of pages7
JournalApplied and Environmental Microbiology
Issue number7
StatePublished - Apr 2011
Externally publishedYes

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Food Science
  • Biotechnology
  • Ecology


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