Genetic control of chloroform toxicity in mice

Richard N. Hill, Thomas L. Clemens, Dai Kee Liu, Elliot S. Vesell, W. Dean Johnson

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Mouse strain differences suggest intermediate or multifactorial genetic control of chloroform-induced renal toxicity and death. The chloroform dose lethal to 50 percent of animals was four times higher in C57BL/6J males than in DBA/2J males. Twice as much chloroform accumulated in the kidneys of the sensitive as the resistant strain. First generation offspring were midway between parental strains for both parameters.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
Issue number4210
StatePublished - Jan 1 1975
Externally publishedYes

ASJC Scopus subject areas

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