Genetic control of chloroform toxicity in mice

Richard N. Hill; Thomas L. Clemens; Dai Kee Liu; Elliot S. Vesell; W. Dean Johnson

doi:10.1126/science.1166306

Genetic control of chloroform toxicity in mice

Richard N. Hill, Thomas L. Clemens, Dai Kee Liu, Elliot S. Vesell, W. Dean Johnson

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39 Scopus citations

Abstract

Mouse strain differences suggest intermediate or multifactorial genetic control of chloroform-induced renal toxicity and death. The chloroform dose lethal to 50 percent of animals was four times higher in C57BL/6J males than in DBA/2J males. Twice as much chloroform accumulated in the kidneys of the sensitive as the resistant strain. First generation offspring were midway between parental strains for both parameters.

Original language	English (US)
Pages (from-to)	159-161
Number of pages	3
Journal	Science
Volume	190
Issue number	4210
DOIs	https://doi.org/10.1126/science.1166306
State	Published - Jan 1 1975
Externally published	Yes

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title = "Genetic control of chloroform toxicity in mice",

abstract = "Mouse strain differences suggest intermediate or multifactorial genetic control of chloroform-induced renal toxicity and death. The chloroform dose lethal to 50 percent of animals was four times higher in C57BL/6J males than in DBA/2J males. Twice as much chloroform accumulated in the kidneys of the sensitive as the resistant strain. First generation offspring were midway between parental strains for both parameters.",

author = "Hill, {Richard N.} and Clemens, {Thomas L.} and Liu, {Dai Kee} and Vesell, {Elliot S.} and Johnson, {W. Dean}",

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AU - Hill, Richard N.

AU - Clemens, Thomas L.

AU - Liu, Dai Kee

AU - Vesell, Elliot S.

AU - Johnson, W. Dean

PY - 1975/1/1

Y1 - 1975/1/1

N2 - Mouse strain differences suggest intermediate or multifactorial genetic control of chloroform-induced renal toxicity and death. The chloroform dose lethal to 50 percent of animals was four times higher in C57BL/6J males than in DBA/2J males. Twice as much chloroform accumulated in the kidneys of the sensitive as the resistant strain. First generation offspring were midway between parental strains for both parameters.

AB - Mouse strain differences suggest intermediate or multifactorial genetic control of chloroform-induced renal toxicity and death. The chloroform dose lethal to 50 percent of animals was four times higher in C57BL/6J males than in DBA/2J males. Twice as much chloroform accumulated in the kidneys of the sensitive as the resistant strain. First generation offspring were midway between parental strains for both parameters.

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Genetic control of chloroform toxicity in mice

Abstract

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