Genetic characterization of HIV-1 from semen and blood from clade C-infected subjects from India and effect of therapy in these body compartments

Chengli Shen; Ming Ding; Jodi K. Craigo; Patrick Tarwater; Ramdas Chatterjee; Pratima Roy; Subhasish K. Guha; Bibhuti Saha; Dolonchapa Modak; Dhrubak Neogi; Yue Chen; Phalguni Gupta

doi:10.1016/j.virol.2010.01.033

Genetic characterization of HIV-1 from semen and blood from clade C-infected subjects from India and effect of therapy in these body compartments

Chengli Shen, Ming Ding, Jodi K. Craigo, Patrick Tarwater, Ramdas Chatterjee, Pratima Roy, Subhasish K. Guha, Bibhuti Saha, Dolonchapa Modak, Dhrubak Neogi, Yue Chen, Phalguni Gupta

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Biologic and genetic differences between HIV-1 clade C in India and clade B in US suggest that the effect of anti-viral therapy in various body compartments may differ between these two clades. We examined the effect of therapy on viral loads in semen and blood of HIV-1-clade C infected subjects from India and evaluated whether HIV-1 in the semen is different from that in blood in these subjects. HIV-1 RNA was detected in semen and blood at all stages of the disease. Viral loads in semen and blood were strongly correlated with each other, but not with the CD4+ T cell count. Anti-viral treatment reduced viral load drastically in blood and semen within one month of post therapy. Genetic characterization of HIV-1 in the semen and blood demonstrated that they were highly compartmentalized. These data have important implications of sexual transmission of HIV-1 in clade C HIV-1 infected subjects.

Original language	English (US)
Pages (from-to)	190-196
Number of pages	7
Journal	Virology
Volume	401
Issue number	2
DOIs	https://doi.org/10.1016/j.virol.2010.01.033
State	Published - Jun 2010
Externally published	Yes

Keywords

Antiretroviral therapy
Clade C HIV-1
Semen

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2010.01.033

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@article{454636ea0a894c1a9ef9973af84ec192,

title = "Genetic characterization of HIV-1 from semen and blood from clade C-infected subjects from India and effect of therapy in these body compartments",

abstract = "Biologic and genetic differences between HIV-1 clade C in India and clade B in US suggest that the effect of anti-viral therapy in various body compartments may differ between these two clades. We examined the effect of therapy on viral loads in semen and blood of HIV-1-clade C infected subjects from India and evaluated whether HIV-1 in the semen is different from that in blood in these subjects. HIV-1 RNA was detected in semen and blood at all stages of the disease. Viral loads in semen and blood were strongly correlated with each other, but not with the CD4+ T cell count. Anti-viral treatment reduced viral load drastically in blood and semen within one month of post therapy. Genetic characterization of HIV-1 in the semen and blood demonstrated that they were highly compartmentalized. These data have important implications of sexual transmission of HIV-1 in clade C HIV-1 infected subjects.",

keywords = "Antiretroviral therapy, Clade C HIV-1, Semen",

author = "Chengli Shen and Ming Ding and Craigo, {Jodi K.} and Patrick Tarwater and Ramdas Chatterjee and Pratima Roy and Guha, {Subhasish K.} and Bibhuti Saha and Dolonchapa Modak and Dhrubak Neogi and Yue Chen and Phalguni Gupta",

note = "Funding Information: This work was supported by a grant R21AI65392 from National Institute of Health . Dr. Chengli Shen was also partially supported by an AIDS International Fogarty grant TW001038-06 .",

year = "2010",

month = jun,

doi = "10.1016/j.virol.2010.01.033",

language = "English (US)",

volume = "401",

pages = "190--196",

journal = "Virology",

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publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Genetic characterization of HIV-1 from semen and blood from clade C-infected subjects from India and effect of therapy in these body compartments

AU - Shen, Chengli

AU - Ding, Ming

AU - Craigo, Jodi K.

AU - Tarwater, Patrick

AU - Chatterjee, Ramdas

AU - Roy, Pratima

AU - Guha, Subhasish K.

AU - Saha, Bibhuti

AU - Modak, Dolonchapa

AU - Neogi, Dhrubak

AU - Chen, Yue

AU - Gupta, Phalguni

N1 - Funding Information: This work was supported by a grant R21AI65392 from National Institute of Health . Dr. Chengli Shen was also partially supported by an AIDS International Fogarty grant TW001038-06 .

PY - 2010/6

Y1 - 2010/6

N2 - Biologic and genetic differences between HIV-1 clade C in India and clade B in US suggest that the effect of anti-viral therapy in various body compartments may differ between these two clades. We examined the effect of therapy on viral loads in semen and blood of HIV-1-clade C infected subjects from India and evaluated whether HIV-1 in the semen is different from that in blood in these subjects. HIV-1 RNA was detected in semen and blood at all stages of the disease. Viral loads in semen and blood were strongly correlated with each other, but not with the CD4+ T cell count. Anti-viral treatment reduced viral load drastically in blood and semen within one month of post therapy. Genetic characterization of HIV-1 in the semen and blood demonstrated that they were highly compartmentalized. These data have important implications of sexual transmission of HIV-1 in clade C HIV-1 infected subjects.

AB - Biologic and genetic differences between HIV-1 clade C in India and clade B in US suggest that the effect of anti-viral therapy in various body compartments may differ between these two clades. We examined the effect of therapy on viral loads in semen and blood of HIV-1-clade C infected subjects from India and evaluated whether HIV-1 in the semen is different from that in blood in these subjects. HIV-1 RNA was detected in semen and blood at all stages of the disease. Viral loads in semen and blood were strongly correlated with each other, but not with the CD4+ T cell count. Anti-viral treatment reduced viral load drastically in blood and semen within one month of post therapy. Genetic characterization of HIV-1 in the semen and blood demonstrated that they were highly compartmentalized. These data have important implications of sexual transmission of HIV-1 in clade C HIV-1 infected subjects.

KW - Antiretroviral therapy

KW - Clade C HIV-1

KW - Semen

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Genetic characterization of HIV-1 from semen and blood from clade C-infected subjects from India and effect of therapy in these body compartments

Abstract

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