TY - JOUR
T1 - Genetic basis of pancreas cancer development and progression
T2 - Insights from whole-exome and whole-genome sequencing
AU - Iacobuzio-Donahue, Christine A.
AU - Velculescu, Victor E.
AU - Wolfgang, Christopher L.
AU - Hruban, Ralph H.
PY - 2012/8/15
Y1 - 2012/8/15
N2 - Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has provided insight into the fundamental pathways that drive the progression from a normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms.
AB - Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has provided insight into the fundamental pathways that drive the progression from a normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms.
UR - http://www.scopus.com/inward/record.url?scp=84865076498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865076498&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-12-0315
DO - 10.1158/1078-0432.CCR-12-0315
M3 - Article
C2 - 22896692
AN - SCOPUS:84865076498
SN - 1078-0432
VL - 18
SP - 4257
EP - 4265
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 16
ER -