Genetic basis of ige responsiveness: Relevance to the atopic diseases

David G. Marsh, John D. Neely, Daniel R. Breazeale, Balaram Ghosh, Linda R. Freidhoff, Carsten Schou, Terri H. Beaty

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Genctic analysis of 170 subjects in 11 extended Amish families revealed evidence for linkage of five markers in chromosome 5q31.l with a gene controlling total serum IgE levels. No linkage was found between these markers and specific IgE antibody levels. Analysis of total IgE within a subset of 128 IgE-antibodynegative sib pairs confirmed evidence for linkage to 5q31.1, especially IL4 (p = 4 x l0-6). These and other data suggest that 1L4 or a nearby gene regulates IgE production in a non-antigen-specific (noncognate) fashion and provide evidence for a possible link between asthma and the.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalInternational archives of allergy and immunology
Issue number1-3
StatePublished - 1995


  • Asthma
  • Gcnctic analysis
  • Igegene
  • Il4
  • Noncognate ige production

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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