Genetic augmentation of Ca2+ channels in cell monolayers: comparing optical recordings and computer simulations of modulated action potentials

Emilia Entcheva, Henry M. Colecraft, David Yue, Raimond Winslow, Leslie Tung

Research output: Contribution to journalConference articlepeer-review

Abstract

Adenoviralmediated overexpression of β2a, 4 subunits was used to influence the electrophysiological behavior of confluent monolayers of cultured neonatal rat ventricular myocytes. Optical action potentials were recorded for control and a-subunit-enhanced monolayers. In general, overexpression of auxiliary β2a, a subunits significantly modulated excitability in hear monolayers.

Original languageEnglish (US)
Pages (from-to)S-53
JournalAnnals of biomedical engineering
Volume28
Issue numberSUPPL. 1
StatePublished - 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

ASJC Scopus subject areas

  • Biomedical Engineering

Fingerprint

Dive into the research topics of 'Genetic augmentation of Ca2+ channels in cell monolayers: comparing optical recordings and computer simulations of modulated action potentials'. Together they form a unique fingerprint.

Cite this