@article{2f17795d3fb9430b88d4d8b079b0739d,
title = "Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus",
abstract = "Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.",
keywords = "Gene polymorphisms, Leptin pathway, Systemic lupus erythematosus",
author = "{The members of GENLES Network} and {The BIOLUPUS network} and Jian Zhao and Hui Wu and Langefeld, {Carl D.} and Kaufman, {Kenneth M.} and Kelly, {Jennifer A.} and Bae, {Sang Cheol} and Alarc{\'o}n-Riquelme, {Marta E.} and Alarc{\'o}n, {Graciela S.} and Anaya, {Juan Manuel} and Criswell, {Lindsey A.} and Freedman, {Barry I.} and Kamen, {Diane L.} and Gilkeson, {Gary S.} and Jacob, {Chaim O.} and James, {Judith A.} and Merrill, {Joan T.} and Gaffney, {Patrick M.} and Sivils, {Kathy Moser} and Niewold, {Timothy B.} and Petri, {Michelle A.} and Song, {Seung Taek} and Jeong, {Hye jin} and Rosalind Ramsey-Goldman and Reveille, {John D.} and {Hal Scofield}, R. and Stevens, {Anne M.} and Boackle, {Susan A.} and Vil{\'a}, {Luis M.} and Chang, {Deh Ming} and Song, {Yeong Wook} and Vyse, {Timothy J.} and Harley, {John B.} and Brown, {Elizabeth E.} and Edberg, {Jeffrey C.} and Kimberly, {Robert P.} and Hahn, {Bevra H.} and Grossman, {Jennifer M.} and Tsao, {Betty P.} and {La Cava}, Antonio and Johan Frosteg{\aa}rd and Lennart Truedsson and {de Ram{\'o}n}, Enrique and Sabio, {Jos{\'e} M.} and Gonz{\'a}lez-Escribano, {Mar{\'i}a F.} and Javier Martin and Norberto Ortego-Centeno and Callejas, {Jos{\'e} Luis} and Julio S{\'a}nchez-Rom{\'a}n and Sandra D'Alfonso and Sergio Migliarese",
note = "Funding Information: We thank all subjects for participation in this study, and Erika Magdangal for help with DNA preparation and organization. This work was supported by the US National Institutes of Health grants AR53239 (A.L.C.) AR043814 and AR065626 (B.P.T.), AI083194 (J.B.H., K.M.S., R.P.K., L.A.C., T.J.V., M.E.A.R., C.O.J., B.P.T. and P.M.G.), AR049084 (R.P.K., J.B.H., J.C.E., E.E.B., G.S.A., J.D.R., R.R.G. and M.A.P.), AR064820 (E.E.B., M.A.P., R.R.G., J.D.R. and L.M.V.), TR001417 (J.C.E. and R.P.K.), CA141700 and AR058621 (M.E.A.R.), AR053308 and TR000004 (L.A.C.), AR062755 and RR029882 (G.S.G. and D.L.K.), AR057172 (C.O.J.), GM103510 , GM104938 , AR053483 , AI101934 and AI082714 (J.A.J.), AI063274 (P.M.G.), AR043274 (K.M.S.), AI083790 , AI071651 and RR024999 (T.B.N.), AR43727 (M.A.P.), AR002138 , AR066464 and TR001422 (R.R.G.), RR023417 (J.D.R.), AR051545 and RR025014 (A.M.S.), AI070304 (S.A.B.), AR042460 , AR062277 , RR020143 and AI024717 (J.B.H.), AR048311 and AR055385 (E.E.B.), AR033062 (R.P.K.). Additional funds were from the Lupus Foundation of America (B.P.T.), the Alliance for Lupus Research (B.P.T., Y.D., K.M.S., T.B.N., L.A.C., C.O.J. and S.A.B.), the Lupus Research Institute (B.P.T. and T.B.N.), the US Department of Veterans Affairs (Merit Awards; J.B.H. and G.S.G.), the US Department of Defense ( PR094002 , J.B.H.), the Arthritis National Research Foundation (Eng Tan Scholar Award; J.Z. and T.B.N.), the Arthritis Foundation (A.M.S. and P.M.G.), the Korea Healthcare Technology R&D Project , Ministry for Health and Welfare, Republic of Korea ( HI13C2124 to S.C.B and HI13C1754 and HI14C1277 to Y.W.S.), the European Science Foundation RNP (BIOLUPUS Research Network), the Wellcome Trust (T.J.V.), Arthritis Research UK (T.J.V.), a Kirkland Scholar Award (L.A.C.), the Wake Forest School of Medicine Center for Public Health Genomics (C.D.L.), and UCLA Clinical and Translational Science Institute (CTSI) RR033176 and TR000124 . Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = dec,
day = "1",
doi = "10.1016/j.clim.2015.09.007",
language = "English (US)",
volume = "161",
pages = "157--162",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "2",
}