Genetic approaches to interfere with malaria transmission by vector mosquitoes

Sibao Wang, Marcelo Jacobs-Lorena

Research output: Contribution to journalReview articlepeer-review

109 Scopus citations

Abstract

Malaria remains one of the most devastating diseases worldwide, causing over 1 million deaths every year. The most vulnerable stages of Plasmodium development in the vector mosquito occur in the midgut lumen, making the midgut a prime target for intervention. Mosquito transgenesis and paratransgenesis are two novel strategies that aim at rendering the vector incapable of sustaining Plasmodium development. Mosquito transgenesis involves direct genetic engineering of the mosquito itself for delivery of anti-. Plasmodium effector molecules. Conversely, paratransgenesis involves the genetic modification of mosquito symbionts for expression of anti-pathogen effector molecules. Here we consider both genetic manipulation strategies for rendering mosquitoes refractory to Plasmodium infection, and discuss challenges for the translation of laboratory findings to field applications.

Original languageEnglish (US)
Pages (from-to)185-193
Number of pages9
JournalTrends in Biotechnology
Volume31
Issue number3
DOIs
StatePublished - Mar 2013
Externally publishedYes

Keywords

  • Effector molecules
  • Malaria
  • Mosquitoes
  • Paratransgenesis
  • Transgenesis

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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