Genetic and Immune Dysregulation in Chronic Rhinosinusitis

Ashleigh Halderman, Andrew P. Lane

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Chronic rhinosinusitis (CRS) is a prevalent condition that is heterogeneous in disease characteristics and multifactorial in cause. Although sinonasal mucosal inflammation in CRS is often either reversible or well-managed medically and surgically, a significant proportion of patients has a refractory form of CRS despite maximal therapy. Two of the several described factors thought to contribute to disease recalcitrance are genetic influences and dysfunction of the host immune system. Current evidence for a genetic basis of CRS is reviewed, as it pertains to putative abnormalities in innate and adaptive immune function. The role of systemic immunodeficiencies in refractory CRS is discussed.

Original languageEnglish (US)
Pages (from-to)13-28
Number of pages16
JournalOtolaryngologic Clinics of North America
Issue number1
StatePublished - Feb 1 2017


  • Chronic rhinosinusitis
  • Chronic rhinosinusitis with nasal polyps
  • Chronic rhinosinusitis without nasal polyps
  • Genetics
  • Immune dysregulation
  • Primary immunodeficiency
  • Single-nucleotide polymorphisms

ASJC Scopus subject areas

  • Otorhinolaryngology


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