Genetic ancestry influences asthma susceptibility and lung function among Latinos

Maria Pino-Yanes, Neeta Thakur, Christopher R. Gignoux, Joshua M. Galanter, Lindsey A. Roth, Celeste Eng, Katherine K. Nishimura, Sam S. Oh, Hita Vora, Scott Huntsman, Elizabeth A. Nguyen, Donglei Hu, Katherine A. Drake, David V. Conti, Andres Moreno-Estrada, Karla Sandoval, Cheryl A. Winkler, Luisa N. Borrell, Fred Lurmann, Talat S. IslamAdam Davis, Harold J. Farber, Kelley Meade, Pedro C. Avila, Denise Serebrisky, Kirsten Bibbins-Domingo, Michael A. Lenoir, Jean G. Ford, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Shannon M. Thyne, Saunak Sen, Jose R. Rodriguez-Santana, Carlos D. Bustamante, L. Keoki Williams, Frank D. Gilliland, W. James Gauderman, Rajesh Kumar, Dara G. Torgerson, Esteban G. Burchard

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Background Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.

Objective To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.

Conclusion Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.

Methods We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.

Results Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10-15), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P =.001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10-5 and -83 ± 19 mL; P = 1.1 x 10-5, respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10-6 and -107 ± 22 mL; P = 1.0 x 10-6, respectively).

Original languageEnglish (US)
Pages (from-to)228-235
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Issue number1
StatePublished - Jan 1 2015


  • Genetic admixture
  • Hispanics
  • childhood asthma
  • minority
  • pulmonary function

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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