TY - JOUR
T1 - Genetic ancestry influences asthma susceptibility and lung function among Latinos
AU - Pino-Yanes, Maria
AU - Thakur, Neeta
AU - Gignoux, Christopher R.
AU - Galanter, Joshua M.
AU - Roth, Lindsey A.
AU - Eng, Celeste
AU - Nishimura, Katherine K.
AU - Oh, Sam S.
AU - Vora, Hita
AU - Huntsman, Scott
AU - Nguyen, Elizabeth A.
AU - Hu, Donglei
AU - Drake, Katherine A.
AU - Conti, David V.
AU - Moreno-Estrada, Andres
AU - Sandoval, Karla
AU - Winkler, Cheryl A.
AU - Borrell, Luisa N.
AU - Lurmann, Fred
AU - Islam, Talat S.
AU - Davis, Adam
AU - Farber, Harold J.
AU - Meade, Kelley
AU - Avila, Pedro C.
AU - Serebrisky, Denise
AU - Bibbins-Domingo, Kirsten
AU - Lenoir, Michael A.
AU - Ford, Jean G.
AU - Brigino-Buenaventura, Emerita
AU - Rodriguez-Cintron, William
AU - Thyne, Shannon M.
AU - Sen, Saunak
AU - Rodriguez-Santana, Jose R.
AU - Bustamante, Carlos D.
AU - Williams, L. Keoki
AU - Gilliland, Frank D.
AU - Gauderman, W. James
AU - Kumar, Rajesh
AU - Torgerson, Dara G.
AU - Burchard, Esteban G.
N1 - Funding Information:
Disclosure of potential conflict of interest: M. Pino-Yanes has received research support from Fundación Ramón Areces and has received lecture fees from Affymetrix. N. Thakur, S. S. Oh, K. K. Nishimura, P. C. Avila, S. Sen, and J. R. Rodriguez-Santana have received research support from the National Institutes of Health . C. R. Gignoux has received research support from the National Institutes of Health (Training Grant T32 GM007175 ) and has stock/stock options in 23andMe. C. A. Winkler has received research support from the National Cancer Institute , National Institutes of Health under the contract HHSN26120080001E . F. Lurmann has been supported by a National Institute of Environmental Health Sciences /UCSF subaward ES015794 . H. J. Farber has received research support from the National Institutes of Health ; is employed by Texas Children's Health Plan; has provided expert testimony for Serpe Jones Andrews Callender and Bell; has received research support from Families of Spinal Muscular Atrophy ; and has received lecture fees and travel support from the American Academy of Pediatrics . K. Bibbins-Domingo has received research support from the National Institutes of Health , the American Heart Association , and the Centers for Disease Control and Prevention and has received fees for lectures and payment for development of a course in epidemiology for Roche employees (Beijing, February 2013). J. G. Ford has received consultancy fees from GlaxoSmithKline. E. Brigino-Buenaventura has received research support, consultancy fees, and travel support from the Sandler Foundation . L. K. Williams has received research support from the National Heart, Lung, and Blood Institute ( R01HL079055 and R01HL118267 ), the National Institute of Allergy and Infectious Diseases ( R01AI079139 ), and the National Institute of Diabetes and Digestive and Kidney Diseases ( R01DK64695 ). W. J. Gauderman has received research support from the National Institute of Environmental Health Sciences and the National Heart, Lung, and Blood Institute . R. Kumar has received research support from the National Heart, Lung, and Blood Institute and the National Institutes of Health . E. G. Burchard has received research support from the National Institutes of Health , the National Institute of Environmental Health Sciences ( ES015794 ), the National Institute on Minority Health and Health Disparities ( P60MD006902 ), and the American Asthma Foundation . C. D. Bustamante is a board member for Personalis Inc, Ancestry.com , and Invitae; has received consultancy fees from 23andme.com , Etalon.com , and National Geographic; has received research support from the National Institutes of Health ; has a patent with Stanford; and has received royalties from Personalis Inc. The rest of the authors declare that they have no relevant conflicts of interest.
Funding Information:
This study was supported in part by National Institutes of Health (NIH) R01-ES015794 , U19-AI077439 , R01-HL088133 , R01-HL078885 , R25-CA113710 , T32-GM007546 , R01-HL004464 , R01-HL104608 to E.G.B., R01AI079139 and R01AI061774 to L.K.W., P30ES007048 , P01ES011627 , R01ES023262 , R01ES021801 to F.G., and K23-HL093023 to R.K.; the National Institute on Minority Health And Health Disparities under award number P60MD006902 to K.B.D and E.G.B. and M01-RR00188 to the Texas Children's Hospital General Clinical Research Center; Flight Attendant Medical Research Institute , RWJF Amos Medical Faculty Development Award, the Sandler Foundation to E.G.B.; the American Asthma Foundation to L.K.W. and E.G.B.; Ernest S. Bazley Grant to P.C.A.; and the National Cancer Institute , National Institutes of Health , under contract HHSN26120080001E by the Intramural Research Program of the National Institutes of Health , National Cancer Institute , Center for Cancer Research to C.A.W. C.R.G. was supported in part by the UCSF Chancellor's Research Fellowship , Dissertation Year Fellowship , and National Institutes of Health Training Grant T32 GM007175 . J.M.G. was supported in part by National Institutes of Health Training Grant T32 ( GM007546 ) and career development awards from the NHLBI K23 (K23HL111636) and NCATS KL2 (KL2TR000143), as well as the Hewett Fellowship. M.P.Y. was funded by a postdoctoral fellowship from Fundación Ramón Areces , Madrid, Spain.
Publisher Copyright:
© 2014 American Academy of Allergy, Asthma & Immunology.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.Objective To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.Conclusion Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.Methods We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.Results Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10-15), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P =.001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10-5 and -83 ± 19 mL; P = 1.1 x 10-5, respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10-6 and -107 ± 22 mL; P = 1.0 x 10-6, respectively).
AB - Background Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.Objective To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.Conclusion Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.Methods We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.Results Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10-15), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P =.001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10-5 and -83 ± 19 mL; P = 1.1 x 10-5, respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10-6 and -107 ± 22 mL; P = 1.0 x 10-6, respectively).
KW - Genetic admixture
KW - Hispanics
KW - childhood asthma
KW - minority
KW - pulmonary function
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U2 - 10.1016/j.jaci.2014.07.053
DO - 10.1016/j.jaci.2014.07.053
M3 - Article
C2 - 25301036
AN - SCOPUS:84920581292
SN - 0091-6749
VL - 135
SP - 228
EP - 235
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 1
ER -